• EDUCATION

Virtual Curriculum Series

"Virtual Curriculum" is a series of lectures designed to provide hematopathology educational resources to pathology trainees affected by the COVID-19 pandemic. The lectures cover relevant topics in bone marrow, lymph node and spleen pathology. Please note that you may submit a question to the presenter using the Q&A feature on each presentation details page.

New lectures will be posted on this page on a regular basis.

Organizers: Sonam Prakash MD, Flavia Rosado MD, and Laura Brown MD

We would also like to highlight the free educational materials in flow cytometry available on the website of the International Clinical Cytometry Society.

Bone Marrow Pathology


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52 minutes

INTRODUCTION TO BONE MARROW INTERPRETATION
Dr. Robert P. Hasserjian, Massacheusetts General Hospital and Harvard Medical School

This is a basic lecture on how to approach the morphologic evaluation of bone marrow biopsy and aspirate specimens, including identifying the hematopoietic lineages as well as the structure, architecture, and cytology of normal marrow. This lecture is intended for residents who have not yet rotated in hematopathology or are just beginning a hematopathology rotation.


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59 minutes

MYELODYSPLASTIC SYNDROMES AND MYELOPROLIFERATIVE NEOPLASMS - PART I: INTRODUCTION & MYELOPROLIFERATIVE NEOPLASMS
Dr. Robert P. Hasserjian, Massacheusetts General Hospital and Harvard Medical School

This first part of the 2-part MDS and MPN lecture series includes an introduction to general principles of diagnosing myeloid neoplasms and the tools needed to effectively diagnose and classify MDS and MPN entities. The diagnosis of myeloproliferative neoplasm (MPN) entities is covered, including morphologic, clinical, and genetic criteria. Diseases covered are chronic myeloid leukemia, chronic neutrophilic leukemia, the JAK2-associated myeloproliferative neoplasms, and eosinophilic neoplasms (including the eosinophilias associated with specific genetic aberrations). This lecture is intended for residents during their hematopathology rotation as well as senior residents and hematopathology fellows wishing to review the principles of MPN diagnosis and classification.


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65 minutes

MYELODYSPLASTIC SYNDROMES AND MYELOPROLIFERATIVE NEOPLASMS - PART II: MYELODYSPLASTIC SYNDROMES
Dr. Robert P. Hasserjian, Massacheusetts General Hospital and Harvard Medical School

This second part of the 2-part MDS and MPN lecture series covers the diagnosis of myelodysplastic syndromes (MDS), including the criteria required to establish a diagnosis of MDS, challenges in distinguishing MDS from non-neoplastic conditions, and the morphology, clinical features, and genetics of each MDS entity in the 2016 WHO Classification. This lecture is intended for residents during their hematopathology rotation as well as senior residents and hematopathology fellows wishing to review the principles of MDS diagnosis and classification.


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43 minutes

ACUTE MYELOID LEUKEMIA
Dr. Olga Weinberg, Boston Children's Hospital

Acute myeloid leukemia (AML) is a neoplasm of immature myeloid cells and is associated with a wide variety of clinical presentations, morphological features, immunophenotypes, and genetic findings. This lecture will address diagnosis of AML with a focus on revised World Health Organization (WHO) classification. In addition, range of ancillary techniques including next generation sequencing and minimal residual disease significance in AML is discussed.


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53 minutes

PLASMA CELL NEOPLASMS
Dr. James R. Cook, Cleveland Clinic

This video describes the diagnostic criteria and pathologic features of plasma cell disorders including multiple myeloma, monoclonal gammopathy of undetermined significance (MGUS), plasma cell leukemia and amyloidosis. Brief suggestions are provided for the workup of bone marrows performed for monoclonal proteins.


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53 minutes

BONE MARROW FAILURE SYNDROMES
Dr. James R. Cook, Cleveland Clinic

This video reviews the clinical and pathologic features in the two major forms of acquired bone marrow failure leading to pancytopenia, aplastic anemia and paroxysmal nocturnal hemoglobinuria, as well as acquired uni-lineage disorders such as pure red cell aplasia, agranulocytosis, and amegakaryocytic thrombocytopenic purpura. Fanconi's anemia is also discussed as a paradigm of congenital bone marrow failure.


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62 minutes

BONE MARROW MANIFESTATIONS OF SYSTEMIC DISEASE
Dr. Dita Gratzinger, Stanford University School of Medicine

Bone Marrow Manifestations of Systemic Disease: When evaluating a bone marrow biopsy, our instinct is to focus on finding the malignancy; however, the bone marrow is also a window into the overall health of the patient. We will explore broad categories of systemic disorders manifesting in the bone marrow, including heritable bone marrow failure, storage and immunodeficiency disorders; infection-related marrow abnormalities; drug/toxin-related abnormalities; nutritional, metabolic and endocrine disorders; and rheumatologic/autoimmune disorders. Recognition of systemic disorders can guide clinical management, and avoid pitfalls of overdiagnosing malignancy.

Lymph Node Pathology


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71 minutes

REACTIVE LYMPHOID HYPERPLASIA: DIAGNOSTIC PITFALLS AND HOW TO AVOID THEM
Dr. Aliyah R. Sohani, Harvard Medical School

This lecture begins with an overview of normal lymph node morphology, followed by a discussion of the basic patterns of reactive lymphoid hyperplasia and how a pattern-based approach can be useful in both recognizing an enlarged lymph node as benign and determining an etiology for the lymphoid hyperplasia. Specific entities with illustrative case examples are reviewed, including toxoplasma, syphilis, dermatopathic and viral lymphadenitis, and Kikuchi-Fujimoto disease, with an emphasis on helpful ancillary testing and pitfalls to be aware of in order to avoid making an erroneous diagnosis of lymphoma. The lecture concludes with some general considerations to keep in mind when evaluating challenging lymph node specimens lacking a straightforward diagnosis.


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53 minutes

IMMUNOHISTOCHEMICAL AIDS FOR THE DIAGNOSIS AND CLASSIFICATION OF LYMPHOPROLIFERATIVE DISORDERS
Dr. Elaine S. Jaffe, National Cancer Institute

This lecture reviews the basic principles of immunohistochemistry for the diagnosis of lymphoma. It covers low grade B-cell neoplasms, Aggressive B-cell lymphomas, peripheral T-cell lymphomas, Hodgkin lymphomas, and Blastic or immature lymphoid neoplasms.


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108 minutes

DEALING WITH THE SMALL B-CELL NEOPLASMS OF LYMPH NODE AND SPLEEN - PART 1
Dr. Steven H. Swerdlow, University of Pittsburgh School of Medicine

This discussion begins with a brief introduction to the approach we use to think about the small B-cell neoplasms, relating them to the normal B-cell maturational sequence and different B-cell compartments. It then covers CLL/SLL, follicular lymphoma, mantle cell lymphoma, lymphoplasmacytic lymphoma, nodal marginal zone lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma - cheating slightly based on the title), splenic marginal zone lymphoma and splenic small B-cell lymphoma/leukemia, unclassifiable. The aim is to present both the basics, concentrating on our diagnostic approach and diagnostic pitfalls, and some more recent observations, recognizing that we cannot cover a topic like this in great depth even in two presentations.


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101 minutes

DEALING WITH THE SMALL B-CELL NEOPLASMS OF LYMPH NODE AND SPLEEN - PART 2
Dr. Steven H. Swerdlow, University of Pittsburgh School of Medicine


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52 minutes

NEW - HODGKIN LYMPHOMA CLASSIFICATION AND DIFFERENTIAL DIAGNOSIS
Dr. Elaine S Jaffe, National Cancer Institute

This lecture reviews the historical background of Hodgkin lymphoma, and the rationale for the current classification system. The major histological subtypes are discussed in detail, with emphasis on distinguishing clinical and pathological features. Areas of emphasis include a discussion of mediastinal grey zone lymphomas, and its biological and clinical significance. EBV-positive B-cell neoplasms resembling classic Hodgkin lymphoma are reviewed.


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39 minutes

NEW - NODULAR LYMPHOCYTE PREDOMINANT HODGKIN LYMPHOMA
Dr. Yaso Natkunam, Stanford University School of Medicine

This lecture discusses the clinicopathologic features and diagnostic approach to nodular lymphocyte predominant Hodgkin lymphoma. Challenges in the recognition of variant immunoarchitectural patterns and the boundaries with T-cell/histiocyte-rich large B cell lymphoma, diffuse large B cell lymphoma and classic Hodgkin lymphoma are discussed along with case examples to illustrate these diagnostic pitfalls.