Virtual Curriculum Series

Dealing with the Small B-cell Neoplasms of Lymph Node and Spleen - Part 1

Dr. Steven H. Swerdlow, University of Pittsburgh School of Medicine

This discussion begins with a brief introduction to the approach we use to think about the small B-cell neoplasms, relating them to the normal B-cell maturational sequence and different B-cell compartments. It then covers CLL/SLL, follicular lymphoma, mantle cell lymphoma, lymphoplasmacytic lymphoma, nodal marginal zone lymphoma, extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma - cheating slightly based on the title), splenic marginal zone lymphoma and splenic small B-cell lymphoma/leukemia, unclassifiable. The aim is to present both the basics, concentrating on our diagnostic approach and diagnostic pitfalls, and some more recent observations, recognizing that we cannot cover a topic like this in great depth even in two presentations.

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