Virtual Curriculum Series

Aggressive B-cell Lymphomas

Dr. Aliyah Sohani, Massachusetts General Hospital and Harvard Medical School

This lecture covers the entities of Burkitt lymphoma, including the provisional entity of Burkitt-like lymphoma with 11q aberration, and its differential diagnosis with other neoplastic and reactive conditions; diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) with an emphasis on morphologic, immunophenotypic and molecular genetic subgroups with prognostic implications; high-grade B-cell lymphoma (HGBCL) with rearrangements involving MYC, BCL2 and/or BCL6; and HGBCL, NOS. Also reviewed are other large cell lymphoma entities, including primary mediastinal (thymic) large B-cell lymphoma and ALK-positive DLBCL.

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