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FRIDAY, SEPTEMBER 5, 2025

7:15 - 8:00 AM BREAK

MORNING COFFEE / EXHIBITS Regency EFG

8:00 - 8:40 AM PLENARY LECTURE

LECTURE 4A Chairs: Katherine Calvo, Olga Weinberg Regency ABC

MDS AND OTHER MYELOID MALIGNANCIES IN GERMLINE PREDISPOSITION SYNDROMES Katherine Calvo. National Institutes of Health Clinical Center

8:40 - 9:20 AM CASE PRESENTATIONS

SESSION 4 - GERMLINE PREDISPOSITION AND PEDIATRIC MDS Chairs: Katherine Calvo, Olga Weinberg Regency ABC

8:40

INTRODUCTION.

8:45

FROM DIAGNOSTIC AMBIGUITY TO GENETIC CLARITY: AML WITH GERMLINE PREDISPOSITION GATA2 DEFICIENCY Michele R Anderson, Justin B Dalton. VCUHS, RICHMOND, VA, USA

8:57

MDS ASSOCIATED WITH GERMLINE GATA2 MUTATION IN AN 8-YEAR-OLD MALE Ukuemi Edema, Pallavi Galera, Nikita Mehta, Josh Somar, Yanming Zhang, Mikhail Roshal. Memorial Sloan Kettering Cancer Center, New York, NY, USA

9:09

MYELOID DISEASE IN THE SETTING OF A GERMLINE SAMD9 MUTATION  Megan C. Smith, Jason R. Schwartz, Ashwini Yenamandra, Emily F. Mason. Vanderbilt University Medical Center, Nashville, TN, USA

9:20 - 9:40 AM BREAK

COFFEE BREAK / EXHIBITS Regency EFG

9:40 - 10:20 AM PLENARY LECTURE

LECTURE 4B Chairs: Katherine Calvo, Olga Weinberg Regency ABC

ADVANCES IN THE MOLECULAR CHARACTERIZATION OF PEDIATRIC AML Jeffery Klco. St Jude Children's Research Hospital

10:20 - 11:20 AM CASE PRESENTATIONS

SESSION 4 - GERMLINE PREDISPOSITION AND PEDIATRIC MDS (CONT'D) Chairs: Katherine Calvo, Olga Weinberg Regency ABC

10:21

MYELOID NEOPLASM WITH PDGFRB FUSION IN THE SETTING OF A GERMLINE RUNX1 MUTATION Karen M Chisholm, Anica M. Wandler, Basma Basha, Sandra D. Bohling. Seattle Children's Hospital, Seattle, WA, USA

10:33

SHWACHMAN-DIAMOND SYNDROME WITH SBDS MUTATIONS, ELANE VUS AND DEL(20Q) INITIALLY MISDIAGNOSED AS SEVERE CONGENITAL NEUTROPENIA Justin Kelley. Vanderbilt University Medical Center, Nashville, TN, USA

10:45

PEDIATRIC MYELODYSPLASTIC SYNDROME ARISING IN FANCONI ANEMIA  Genevieve Parecki1, Guang Fan1, Susan B. Olson2, Philipp W. Raess1, Todd P. Williams1. 1Oregon Health & Science University, Portland, OR, USA. 2Molecular and Medical Genetics, OHSU, Knight Diagnostic Labs, Portland, OR, USA

10:57

SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

SYSTEMIC MASTOCYTOSIS AND MALIGNANT GERM CELL TUMOR WITH SHARED KIT D816V MUTATION Naomi E Akagi, Parul Bhargava, Karthik Ganapathi. University of California San Francisco, San Francisco, CA, USA

THE MIRAGE OF GERMLINE PREDISPOSITION SYNDROMES Ahmed A Aljudi, Sunita I Park. Children's Healthcare of Atlanta, Atlanta, GA, USA

DEVELOPMENT OF MYELODYSPLASTIC SYNDROME IN A CHILD WITH A FAMILY HISTORY OF GATA2 DEFICIENCY Ahmad Alshomrani1, Danielle Arnold1, Dennis Hickstein1, Steven Holland2, Katherine Calvo3. 1National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA. 3Clinical Center, National Institutes of Health, Bethesda, MD, USA

FAMILIAL THROMBOCYTOPENIA WITH SECONDARY ERYTHROCYTOSIS: A CASE REPORT OF GERMLINE ANKRD26 MUTATION Ahmed Arfa, Todd Knepper, Oluwatobi Ozoya, Mohammed Hussaini, Ling Zhang, Hammad Tashkandi. H Lee Moffitt Cancer Center, Tampa, FL, USA

A YOUNG PATIENT WITH DEFICIENCY OF ADENOSINE DEAMINASE �" 2 MISDIAGNOSED AS DIAMOND BLACKFAN ANEMIA Jayalakshmi Balakrishna1, Thailynn Glover2, Lorena Wilson3, Amanda Ombrello3, Daniel Kastner3, Katherine Calvo4. 1Roswell Park Cancer Center, Buffalo, NY, USA. 2Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA. 3National Human Genome Institute, NIH, Bethesda, MD, USA. 4National Human Genome Institute, NIH, Bethesda, MD, USA. 5National Human Genome Institute, NIH, Bethesda, MD, USA. 6Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD, USA

GERMLINE GATA2 MUTATION AND MULTIPLY RELAPSED/REFRACTORY MDS/AML WITH WIDESPREAD GRANULOCYTIC SARCOMAS. Michael G. Daniel, Jeffrey A. Thomas, Mahesh Mansukhani, Amy Ku, Wen-Hsuan Lin, Craig Soderquist, Govind Bhagat, Bachir Alobeid. Department of Pathology and Cell Biology, NYP-Columbia University Irving Medical Center, New York, NY, USA

A MYELODYSPLASTIC NEOPLASM WITH AN SF3B1 MUTATION IN THE SETTING OF FANCONI ANEMIA Giby V George1, W Richard Burack1, Siba El Hussein2. 1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. 2Department of Pathology, University of Vermont, Burlington, VT, USA

MYELODYSPLASTIC SYNDROME DUE TO INSERTIONAL MUTAGENESIS INTO THE MECOM LOCUS AFTER CORRECTIVE GENE THERAPY  FOR ADRENOLEUKODYSTROPHY Bartosz Grzywacz. Beth Israel Deaconess Medical Center, Boston, MA, USA

MYELOID NEOPLASM WITH AN UNUSUAL CLINICAL PRESENTATION  Anurag Khanna , Brooj Abro. Emory University School of Medicine, Atlanta, GA, USA

MDS/AML WITH KMT2A REARRANGEMENT IN A HYPOCELLULAR MARROW Priya Kumar, Jeffery Klco, Clifford Takemoto, Marcin Wlodarski, Lu Wang, Yen Liu. St Jude Children's Research Hospital, Memphis, TN, USA

CHILDHOOD MYELODYSPLASTIC NEOPLASM WITH LOW BLASTS (CMDS-LB) ASSOCIATED WTIH GERMLINE SAMD9 MUTATION AND MIRAGE SYNDROME Tiffany Lee, Joshua Menke. Stanford University, Palo Alto, CA, USA

RARE CASE OF T-CELL LARGE GRANULAR LYMPHOCYTIC LEUKEMIA IN A PEDIATRIC PATIENT PRESENTING WITH SEVERE NEUTROPENIA.   Jane Lin, Gholamali Jafari, Raavi Gupta. SUNY Downstate Hospital, Brooklyn, NY, USA

GATA-2 HAPLOINSUFFICIENCY PRESENTING WITH MILD LEUKOPENIA, POSITIVE ANTI-NUCLEAR ANTIBODIES, PULMONARY EMBOLISM Nicolas Lopez-Hisijos. Vanderbilt University Medical Center, Nashville, TN, USA

CHILDHOOD MYELODYSPLASTIC SYNDROME WITH MONOSOMY 7 AND CSF3R, ASXL1 AND SETBP1 MUTATIONS Shikha Malhotra, Ellie Hong, Colleen Matthews, Elizabeth Cummings, Mahmoud Aarabi, Bryan Rea, Nidhi Aggarwal. University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA

MYELODYSPLASTIC NEOPLASM WITH BIALLELIC TP53 INACTIVATION (WHO-HAEM5) / MYELODYSPLASIA WITH MUTATED TP53 (ICC2022) IN THE SETTING OF SCHWACHMAN DIAMOND SYNDROME Rachel A Mariani1, 2. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA

MDS/AML IN THE SETTING OF 2 GERMLINE PREDISPOSITION SYNDROMES (FANCONI ANEMIA AND GERMLINE RUNX1 PATHOLOGIC VARIANT) Rachel A. Mariani1, 2. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA

EVOLVING MYELODYSPLASTIC NEOPLASM (MDS) IN A YOUNG PATIENT  Ekaterina Menshikova1, Thomas Schneider2, Brooj Abro1. 1Emory University School of Medicine, Atlanta, GA, USA. 2Tempus, Durham, NC, USA

MYELODYSPLASTIC SYNDROME AND EBV-POSITIVE LYMPHOPROLIFERATIVE DISORDER IN A YOUNG MAN WITH A GERMLINE RUNX1 MUTATION Meredith M. Nichols1, Claudiu V. Cotta2, Karl S. Theil1, Megan O. Nakashima1. 1Cleveland Clinic, Cleveland, OH, USA. 2Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA

MYELODYSPLASTIC SYNDROME/NEOPLASM IN A PATIENT WITH GERMLINE GATA2 MUTATION. Ifeyinwa E Obiorah, Jinbo Fan, Elizabeth Courville. University of Virginia Health system, Charlottesville, VA, USA

GATA2 DEFICIENCY SYNDROME Alma R Oskarsdottir, Jess F Peterson, Kaaren K Reichard. Mayo Clinic, Rochester, MN, USA

GATA2-MDS: A CASE OF HYPOCELLULAR BONE MARROW WITH DYSMEGAKARYOPOIESIS AND GERMLINE PREDISPOSITION Tobi Ozoya1, 2, Ahmed Arfa1, 2, Todd Knepper2, Rohit Sharma2, Mohammed Hussaini2, Ling Zhang1, 2. 1University of South Florida, Tampa, FL, USA. 2H. Lee Moffitt Cancer Center, Tampa, FL, USA

REFRACTORY CYTOPENIA OF CHILDHOOD WITH ASSOCIATED MUTATION IN SAMD9 IN MIRAGE SYNDROME   NAGEHAN PAKASTICALI1, JESSE JASO1, MIGUEL CANTU1, CHRISTIAN WYSOCKI2, OLGA WEINBERG1, KATHRYN DICKERSON2, WEINA CHEN1. 1Department of Hematopathology, UT Southwestern, Dallas, TX, USA. 2Department of Pediatrics, UT Southwestern, Dallas, TX, USA

ANTICIPATING THE MALIGNANT TRANSFORMATION OF SEVERE CONGENITAL NEUTROPENIA IN CONSIDERATION OF BONE MARROW TRANSPLANTATION​ Xenia Parisi, Chi Young Ok. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

MYELOID NEOPLASM ASSOCIATED WITH GATA2 GERMLINE PREDISPOSITION, CONCURRENT RUNX1 MUTATION AND A COMPLEX KARYOTYPE You-Wen Qian, Sheila Jani Sait, Vydia Nagrale. Roswell Park Cancer Center, Buffalo, NY, USA

CHILDHOOD MYELODYSPLASTIC NEOPLASM WITH COMPLEX KARYOTYPE AND MOLECULAR ABNORMALITIES Luis F Quistian, Dona Kanavy, Jason D. Merker, Yuri Fedoriw, Danielle L. V. Maracaja. University of North Carolina, Chapel Hill, NC, USA

COPPER DEFICIENCY AND VITAMIN C DEFICIENCY PRESENTING AS EVOLVING CYTOPENIAS AND BONE MARROW DYSPLASIA IN A CHILD WITH GOLLOP-WOLFGANG COMPLEX Eman Sallam, Ping Shi, Michael G. Bayerl, Erik Washburn. Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

MYELODYSPLASTIC SYNDROME IN THE SETTING OF GERMLINE RUNX1 FAMILIAL PLATELET DISORDER ASSOCIATED WITH MYELOID MALIGNANCY (FPDMM). Michelly Sampaio de Melo1, Weixin Wang1, David J. Young2, Shawn Chong3, Natalie Deuitch 3, Joie Davis3, Kathleen Craft 3, Paul P Liu3, Katherine R. Calvo1. 1Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA. 2National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, USA. 3National Human Genome Research Institute, NIH, Bethesda, MD, USA

MDS ARISING FROM A MEDIASTINAL GERM CELL TUMOR Jeffrey Thomas1, Michael Daniel2, Amy Ku3, Criag Soderquist4, Bachir Alobeid5, Govind Bhagat6. 1Columbia University Irving Medical Center, New York City, NY, USA. 2Columbia University Irving Medical Center, New York City, NY, USA. 3Columbia University Irving Medical Center, New York City, NY, USA. 4Columbia University Irving Medical Center, New York City, NY, USA. 5Columbia University Irving Medical Center, New York City, NY, USA. 6Columbia University Irving Medical Center, New York City, NY, USA

CHILDHOOD MYELODYSPLASTIC NEOPLASM WITH LOW BLASTS IN A NINE-WEEK-OLD INFANT WITH MONOSOMY 7 Xin Wang1, Maria Faraz1, Noureldien Darwish1, Meng Liu1, Xiaoyan Huang1, 2, Tipu Nazeer1. 1Department of Pathology, Albany Medical Center, Albany, NY, USA. 2Department of pathology, New York University Langone Health, New York, NY, USA

11:20 - 12:00 PM CASE PRESENTATIONS

SESSION 5 - EBV POSITIVE LYMPHOMAS Chairs: Alexandra Kovach, Michele Paessler, Stefania Pittaluga Regency ABC

11:20

INTRODUCTION.

11:25

EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA IN A PATIENT WITH CD8 DEFICIENCY Hariharan S. Bharadwaj1, 2, Jacob Bledsoe1. 1Boston Children's Hospital, Boston, MA, USA. 2Brigham & Women's Hospital, Boston, MA, USA

11:37

EXTRANODAL NK/T-CELL LYMPHOMA OF THE TRANSVERSE COLON PRESENTING AS INTESTINAL PERFORATION IN AN ADOLESCENT Ingrid S Tam1, Kris Milbrandt2, Paul D'Alessandro3, Yue Wu1, 4. 1Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada. 2Department of Surgery, University of Saskatchewan, Saskatoon, SK, Canada. 3Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada. 4Saskatchewan Health Authority, Saskatoon, SK, Canada

11:49

HYDROA VACCINIFORME LYMPHOPROLIFERATIVE DISORDER WITH KMT2D MUTATION AND DELETION. Aleksander Luniewski1, Sonia Toussaint2, Adriana Valencia3, Ifeyinwa E Obiorah1. 1University of Virginia Health system, Charlottesville, VA, USA. 2Dr. Manuel Gea Gonzalez and National Autonomous University, Mexico city Mexico. 3Hospital Infantil de Mexico and National Autonomous University, Mexico, Mexico city Mexico

12:00 - 1:00 PM LUNCH ON YOUR OWN

LUNCH ON YOUR OWN

1:00 - 1:40 PM PLENARY LECTURE

LECTURE 5 Chairs: Alexandra Kovach, Michele Paessler, Stefania Pittaluga Regency ABC

BIOLOGY AND TREATMENT OF EBV-DRIVEN LYMPHOPROLIFERATIVE DISORDERS IN PEDIATRIC/AYA POPULATIONS Catherine Bollard. Children's National Hospital

1:40 - 2:40 PM CASE PRESENTATIONS

SESSION 5 - EBV POSITIVE LYMPHOMAS (CONT'D) Chairs: Alexandra Kovach, Michele Paessler, Stefania Pittaluga Regency ABC

1:41

CHRONIC ACTIVE EBV INFECTION IN PATIENT WITH 3Q13 DELETION SYNDROME Sandra D. Bohling1, Basma Bash1, Jason E. Love2, Karen M. Chisholm1. 1Seattle Children's Hospital, Seattle, WA, USA. 2University of Washington, Seattle, WA, USA

1:53

A CASE OF SYSTEMIC EBV-POSITIVE T-CELL LYMPHOMA OF CHILDHOOD WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Jingwei Li, David Grier, Robert Lorsbach. Division of Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

2:05

DIAGNOSTIC CHALLENGES OF EBV+ CLASSIC HODGKIN LYMPHOMA IN CHILDREN. Matan Kadosh1, Avi Kandel2, Caitlin Harmon1, Faryal Fatima1, Christian Salib2, Bruce Petersen2, Dalia Abdel-Azim2, Alina Dulau-Florea2, Amy Duffield2, Shafinaz Hussein2. 1Mount Sinai West Hospital, Icahn School of Medicine, New York, NY, USA. 2Mount Sinai Hospital, Icahn School of Medicine, New York, NY, USA

2:17

SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

SYSTEMIC EPSTEIN-BARR-VIRUS-POSITIVE T CELL LYMPHOMA OF CHILDHOOD olga balagué1, lucia ferrando2, ramiro alvarez2, leonie frauenfeld1. 1Hospital Clinic, Barcelona, Spain. 2Hospital Miguel Servet, Zaragoza, Spain

EBV-POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA IN A PATIENT WITH ATAXIA TELANGIECTASIA Hariharan S. Bharadwaj1, 2, Jacob Bledsoe1. 1Boston Children's Hospital, Boston, MA, USA. 2Brigham & Women's Hospital, Boston, MA, USA

EBV+ CD8+ CYTOTOXIC MOLECULE POSITIVE PTCL/MONOMORPHIC PTLD ASSOCIATED WITH HLH Michael G. Daniel, Jeffrey A. Thomas, Mahesh Mansukhani, Amy Ku, Wen-Hsuan Lin, Craig Soderquist, Govind Bhagat, Bachir Alobeid. Department of Pathology and Cell Biology, NYP-Columbia University Irving Medical Center, New York, NY, USA

NON-IGH::BCL2 REARRANGED FOLLICULAR LYMPHOMA PROGRESSING TO DIFFUSE LARGE B CELL LYMPHOMA IN A PATIENT WITH WISKOTT-ALDRICH SYNDROME AND EBV VIREMIA: B-CELL LYMPHOMA ARISING IN A BACKGROUND OF IMMUNODEFICIENCY AND DYSREGULATION. Luiz Paulo De Lima Guido, Jennifer R Chapman. University of Miami, Miami, FL, USA

EBV POSITIVE  NODAL T CELL LYMPHOMA IN CHILD WITH HEART TRANSPLANT FOR WOLFF PARKINSON WHITE SYNDROME Samreen Fathima1, Sophia Yohe1, Theodros Mamo1, Amy Beckman1, Ismail Elbaz Younes1, Mehrnoosh Tashakori 1, Cade Arries1, Michael Linden1. 1University of Minnesota, Minneapolis, MN, USA. 2University of Minnesota, Minneapolis, MN, USA. 3University of Minnesota, Minneapolis, MN, USA. 4University of Minnesota, Minneapolis, MN, USA. 5University of Minnesota, Minneapolis, MN, USA. 6University of Minnesota, Minneapolis, MN, USA. 7University of Minnesota, Minneapolis, MN, USA. 8University of Minnesota, Minneapolis, MN, USA

AT THE CROSSROADS OF SYSTEMIC HYDROA VACCINIFORME LYMPHOPROLIFERATIVE DISORDER AND CHRONIC ACTIVE EBV: A DIAGNOSTIC PUZZLE Abdallah Flaifel1, Parul Bhargava2, Jarish Cohen2, 3, Jeffrey Cohen4, Elaine S. Jaffe1. 1Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2Department of Pathology and Lab Medicine, University of California, San Francisco, San Francisco, CA, USA. 3Department of Dermatology, University of California, San Francisco, San Francisco, CA, USA. 4Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. 5Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

EBV+ EXTRANODAL T-CELL LYMPHOMA FOLLOWING CLASSIC HYDROA VACCINIFORME LYMPHOPROLIFERATIVE DISORDER Giby V George1, Jamie E Flerlage2, Andrew G Evans1. 1Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA. 2Department of Hematology and Oncology, University of Rochester Medical Center, Rochester, NY, USA

A 16-YEAR-OLD MALE WITH MEDIASTINAL MASS AND RIGHT AXILLARY/CHEST SWELLING Shunyou Gong. Northwestern University, Chicago, IL, USA

EBV-POSITIVE POST-TRANSPLANT LYMPHOPROLIFERATIVE DISORDER WITH LYMPHOMATOID GRANULOMATOSIS FEATURES IN A 20-YEAR-OLD Rohiverth Guarecuco Jr. 1, 2, Mark D. Fleming2, Jacob R. Bledsoe2. 1Mass General Brigham, Boston, MA, USA. 2Boston Children's Hospital, Boston, MA, USA

EBV POSITIVE DIFFUSE LARGE B-CELL LYMPHOMA IN THE SETTING OF COMMON VARIABLE IMMUNODEFICIENCY AND POST-RITUXIMAB THERAPY Jasmine N. Jefferson1, Priya Kumar2, Yukiko Kitagawa3, Gabriela Gheorghe2. 1University of TN Health Science Center, Memphis, TN, USA. 2St. Jude Children's Research Hospital, Memphis, TN, USA. 3NIH/NCI, Bethesda, MD, USA

CHRONIC ACTIVE EBV DISEASE COMPLICATED BY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS AND PROGRESSION TO BONE MARROW INVOLVEMENT BY AN EBV-POSITIVE NK-CELL LYMPHOMA Clarissa E. Jordan, April Chiu, Kaaren K. Reichard, Ellen D. McPhail, Andrew L. Feldman, Rong He, Min Shi, Ji (Jane) Yuan, Rebecca L. King. Mayo Clinic, Rochester, MN, USA

CHRONIC ACTIVE EBV DISEASE FOLLOWING SOLID ORGAN TRANSPLANTATION: A RARE AND AGGRESSIVE MANIFESTATION Alexandra E. Kovach1, 2, Karin P. Miller1, 2, Endi Wang2, 3, Imran Siddiqi2, 3, Gordana Raca1, 2, Andrew Doan2, 4, Miya Villaneuva4, Paibel Aguayo-Hiraldo2, 4, Elaine S. Jaffe5, Stefania Pittaluga5. 1Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, CA, USA. 2Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 3Department of Pathology, University of Southern California, Los Angeles, CA, USA. 4Hematology/Oncology, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, USA. 5Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

26 YEAR-OLD-MALE WITH ACUTE SECONDARY HLH IN THE SETTING OF CAEBV DEVELOPS UNSUAL MALIGNANCY Brian Lockhart1, Michele Paessler1, 2, Gerald Wertheim1, 2. 1Children's Hospital of Philadelphia, Philadelphia, PA, USA. 2University of Pennsylvania, Philadelphia, PA, USA

PRIMARY EXTRANODAL NK/T-CELL LYMPHOMA INVOLVING THE CENTRAL NERVOUS SYSTEM OF A 25-YEAR-OLD MALE, EBV-POSITIVE Georgi Lukose, Ivo SahBandar, Chandler Sy, Julia Geyer. Weill Cornell Medicine/ NewYork-Presbyterian, New York, NY, USA

EBV-POSITIVE LARGE B-CELL LYMPHOMA Matthew Xi Luo1, Jonathan Fromm1, Kikkeri Naresh1, 2, Xueyan Chen1, 2. 1University of Washington, Seattle, WA, USA. 2Fred Hutch Cancer Center, Seattle, WA, USA

INTESTINAL PSEUDOPOLYP AS A COMPLICATION OF CHRONIC ACTIVE EBV DISEASE  Saumyaranjan Mallick1, Surabhi Jain1, Jagdish P Meena2, Rachana Steh2, Shradhanjali Satpathy1. 1Department of Pathology, ALl India Institute of Medical Sciences, New Delhi India. 2Department of Pathology, ALl India Institute of Medical Sciences, New Delhi India. 3Department of Pediatrics, ALl India Institute of Medical Sciences, New Delhi India

OVERT SYSTEMIC EBV-POSITIVE T-CELL LYMPHOMA OF CHILDHOOD IN PERSISTENT EBV-POSITIVE HLH WITH GENETIC VARIANTS OF UNKNOWN SIGNIFICANCE IDENTIFIED BY CLINICAL GENOMIC PROFILING Vicki Mercado-Evans, Kevin Fisher, Andrea Marcogliese, Tarek Elghetany, Choladda Curry. Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA

HYDROA VACCINIFORME IN A 7-YEAR-OLD MALE Dingani Nkosi1, 2, Marian Harris2, Birgitta Schmidt2, Jacob R. Bledsoe2. 1Mass General Brigham, Boston, MA, USA. 2Boston Children's Hospital, Boston, MA, USA

UNEXPECTED CAUSE FOR RECURRENT FEVERS IN A 3 YEAR OLD MALE PATIENT  Dingani Nkosi1, 2, Jacob Bledsoe1, 2. 1Mass General Brigham, Boston, MA, USA. 2Boston Children's Hospital, Boston, MA, USA

EBV-POSITIVE LARGE B-CELL LYMPHOMA IN A YOUNG ADULT WITH NO KNOWN IMMUNODEFICIENCY  Anna B. Owczarczyk1, 2, Kelly A. Bowers1. 1Cleveland Clinic Diagnostics Institute Department of Pathology and Laboratory Medicine​, Cleveland, OH, USA. 2Cleveland Clinic Lerner College of Medicine of Case Western Reserve University School of Medicine, Cleveland, OH, USA

SYSTEMIC EBV POSITIVE T-CELL LYMPHOMA OF CHILDHOOD PRESENTING IN A 17 MONTH OLD BOY Sunita I Park, Ahmed Aljudi, Mohamed Elkhalifa, Elizabeth Weinzierl. Children's Healthcare of Atlanta, Atlanta, GA, USA

EBV-POSITIVE NK-CELL LYMPHOPROLIFERATION IN SPLEEN Leticia Quintanilla-Fend1, Anna Green2. 1University Hospital Tuebingen, Tuebingen, Germany. 2Guy´s and St Thomas NHS, London, United Kingdom

A HIGH BARR: CLINICOPATHOLOGIC OVERLAP OF ACUTE EBV+ T-CELL LYMPHOPROLIFERATIVE DISORDERS Obaid Ur Rehman1, Stephanie N Hurwitz1, 2. 1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA. 2Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN, USA

SINONASAL MASS IN A TEENAGER Daniel J. Robbins. Children's Mercy Hospital, Kansas City, MO, USA

10-YEAR-OLD MALE WITH EBV-POSITIVE NK CELL LEUKEMIA/LYMPHOMA Ivo N. Sah Bandar1, Chandler Sy1, Georgi Lukose1, Nitya Gulati2, Jaclyn Rosenzweig2, Lisa Giulino-Roth2, Julia T. Geyer1. 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. 2Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA

EBV POSITIVE LARGE B-CELL LYMPHOMA IN IMMUNE DYSREGULATION (IPEX SYNDROME) AND IATROGENIC IMMUNOSUPPRESSIVE THERAPY Eman Sallam, Ping Shi, Erik Washburn, Michael G. Bayerl. Penn State Milton S. Hershey Medical Center, Hershey, PA, USA

SERINE/THREONINE-PROTEIN KINASE 4 (STK4) DEFICIENCY & EPSTEIN-BARR VIRUS (EBV) ASSOCIATED POLYMORPHIC LYMPHOPROLIFERATIVE DISORDER Ashish Shah1, Priti Mehta2, Anita Borges1. 1Centre for Oncopathology, Mumbai, India. 2NH SRCC Childrens Hospital, Mumbai, India

CHRONIC ACTIVE EBV INFECTION T/NK CELL TYPE PROGRESSING TO EBV + NK/T CELL LYMPHOMA IN CHILD Tanuja Shet1, Sridhar Epari 2, Nirmalaya Moulik3, Chetan Dhamne 3. 1Dept Of Pathology, Tata Memorial Center, Mumbai, Mumbai India. 2Dept of Pathology, ACTREC and Tata Memorial Hospital, Mumbai India. 3Dept Of Pediatric Hematolymphoid Malignancies, Mumbai India

MUCOSAL CLONAL CD30+ EBV+ GAMMA-DELTA T-CELL LYMPHOPROLIFERATIVE DISORDER, ARISING IN THE CONTEXT OF CHRONIC ACTIVE EBV DISEASE (CAEBV), WITH INDOLENT CLINICAL COURSE. Joan Somja1, Bettina Bisig2, Patrick Collins1, Benoît Florkin3, Pierre Lovinfosse4, Yves Gilon5, Laurence de Leval2. 1Department of Pathology, University Hospital Center, Liège, Belgium. 2Institute of Pathology, Department of Laboratory Medicine and Pathology, University Hospital, Lausanne, Switzerland. 3Department of Pediatry, Citadelle Hospital, Liège, Belgium. 4Department of Nuclear Medicine, University Hospital Center, Liège, Belgium. 5Department of Maxillofacial and Plastic Surgery, University Hospital Center, Liège, Belgium

EXTRANODAL NK/T-CELL LYMPHOMA Tecla Temu1, Patricia Okiro2, Aliyah Sohani1. 1Mass general Brigham, Boston, MA, USA. 2Aghakhan Hospital, Nairobi, Kenya

EBV-POSITIVE MUCOCUTANEOUS ULCER IN A 21-YEAR-OLD MALE Andrew L. Valesano, Anamarija M. Perry. University of Michigan Department of Pathology, Ann Arbor, MI, USA

BONE MARROW AND LIVER INVOLVEMENT BY ATYPICAL EBV-POSITIVE T CELL INFILTRATE ASSOCIATED WITH HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS Aaron J. Wilk, Brent Tan. Stanford University School of Medicine, Stanford, CA, USA

PLASMABLASTIC LYMPHOMA IN AN HIV POSITIVE 7-YEAR-OLD GIRL. Julian DS Willett, Ivo Sah Bandar, Georgi Lukose, Chandler Sy, Amy Chadburn. Pathology & Laboratory Medicine, NewYork-Presbyterian/Weill Cornell Medicine, New York, NY, USA

SYSTEMIC EBV+ T-CELL LYMPHOMA OF CHILDHOOD Jahg Wong1, Sarah-Jeanne Pilon1, 2. 1Universite de Montreal, Montreal, QC, Canada. 2Hopital Maisonneuve-Rosemont, Montreal, QC, Canada

SYSTEMIC EBV-POSITIVE T-CELL LYMPHOMA OF CHILDHOOD Jessie Xiong, Amirah Kuzu, Kathryn M. Harmoney, David R. Czuchlewski. University of New Mexico Health Sciences Center, Albuquerque, NM, USA

A CASE OF SMALL CELL VARIANT OF ALK-POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) WITH LEUKEMIC PRESENTATION MIMICKING NK CELL LEUKEMIA/LYMPHOMA IN A PEDIATRIC PATIENT Charles Yin, Dalila Villalobos. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada

2:40 - 3:00 PM BREAK

COFFEE BREAK / EXHIBITS Regency EFG

3:00 - 4:30 PM CASE PRESENTATIONS

SESSION 6 - SYSTEMIC HIGH-GRADE B-CELL LYMPHOMAS Chairs: David Grier, Thierry Molina, Stefania Pittaluga Regency ABC

3:00

INTRODUCTION.

3:05

A PEDIATRIC CASE OF HIGH GRADE B-CELL LYMPHOMA Audrey McCloskey, Joseph Lownick, Celeste Eno, Jerry Wong. Cedars-Sinai Medical Center, Los Angeles, CA, USA

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LARGE B-CELL LYMPHOMA WITH 11Q ABERRATION Leonie Frauenfeld1, 2, Julia Salmeron-Villalobos2, Itziar Salaverria2, Olga Balague1, 2. 1Hematopathology Section, Laboratory of Pathology, Hospital Clinic, Barcelona, Spain. 2Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

3:29

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT PRESENT IN THE SMALL BOWEL OF AN 8-YEAR-OLD BOY Karen M Chisholm, Sandra D. Bohling. Seattle Children's Hospital, Seattle, WA, USA

3:41

T-CELL HISTIOCYTE RICH LARGE B-CELL LYMPHOMA PRESENTING WITH PARANEOPLASTIC HYPOALBUMINEMIA AND COAGULATION DISORDER IN AN ADOLESCENT Laurence de Leval1, Bettina Bisig1, Simona Stoykova1, Pinelopi Argyriou1, Calogero Mazzara2, Francesco Ceppi2. 1Institute of Pathology, University Hospital Lausanne, Lausanne, Switzerland. 2Department of Pediatrics, University Hospital Lausanne, Lausanne, Switzerland

3:53

A CASE OF CONGENITAL DIFFUSE LARGE B-CELL LYMPHOMA, NOS Jingwei Li1, Robert Lorsbach1, Parsa Hodjat1, David Grier1, Nives Zimmermann2. 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. 2University of Cincinnati College of Medicine, Cincinnati, OH, USA

4:05

SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

PRIMARY PEDIATRIC SMALL INTESTINAL DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) Mercy Akaraonye, Chika Iguh, Xin Qing, Sava Grujic. Habor- UCLA Medical Center, Torrance, CA, USA

HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED, IN A YOUNG ADULT Cade Arries, Michele Dolan, Amy Beckman, Ismal Elbaz Younes, Mehrnoosh Tashakori, Michael Linden. University of Minnesota, Minneapolis, MN, USA

T-CELL/HISTIOCYTES RICH LARGE B-CELL LYMPHOMA Rahmah M Arwani, Candace Reveles. University of Arizona, Tucson, AZ, USA

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT MIMICKING BACTERIAL PHARYNGITIS WITH A PERITONSILLAR ABSCESS​ Stephen Babcock1, 2, Judith Ferry1, 2. 1Massachusetts General Hospital, Boston, MA, USA. 2Harvard Medical School, Boston, MA, USA

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT Linnea S. Banker, Soumya Mikkilineni, Richard D. Hammer. University of Missouri, Columbia, MO, USA

LARGE B-CELL LYMPHOMA (LBCL) WITH IRF4 REARRANGEMENT (LBCL-IRF4-R) Ibidunni O. Bode-Sojobi, Marian H. Harris, Jacob R. Bledsoe. Boston Children Hospital, Boston, MA, USA

A 9-YEAR-OLD FEMALE WITH A SLOWLY GROWING ADENOID MASS Kevin Côté1, Van-Hung Nguyen2, René P. Michel2, Nadine Demko2. 1CHU Sainte-Justine, Montréal, QC, Canada. 2McGill University, Montréal, QC, Canada

HIGH-GRADE B-CELL LYMPHOMA WITH 11Q ABERRATION Maria Chen1, 3, Scott Ryall2, 3, Megan Fitzpatrick1, 3. 1Department of Pathology, Massachusetts General Hospital, Boston, MA, USA. 2Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. 3Harvard Medical School, Boston, MA, USA

BCL-2-POSITIVE HIGH-GRADE B-CELL LYMPHOMA IN A YOUNG ADULT Jorge Cheverez Ocasio, Michelle Dolan, Samreen Fathima, Ismail Elbaz Younes, Mehrnoosh Tashakori, Michael Linden. University of Minnesota, Minneapolis, MN, USA

SURFACE LIGHT CHAIN NEGATIVE BURKITT LYMPHOMA WITH LEUKEMIC PRESENTATION IN A MALE INFANT: AN UNUSUAL CASE AND DIAGNOSTIC PITFALL Genevieve M Crane, Heesun J Rogers. Cleveland Clinic, Cleveland, OH, USA

CD30-POSITIVE LYMPHOMA OF UNDEFINED LINEAGE IN 18 Y/O MALE.   Andres Madrigal. The Ohio State University, Columbus, OH, USA

HIGH-GRADE/LARGE B-CELL LYMPHOMA WITH CONCURRENT MYC REARRANGEMENT AND 11Q ABERRATIONS Rachel Mariani1, 2, Katherine Rudd3, 4, Robert Ohgami3, 4, Kristian Schafernak1, 2. 1Phoenix Children's Hospital, Division of Pathology and Laboratory Medicine, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. 3ARUP Laboratories, Salt Lake City, UT, USA. 4University of Utah, Salt Lake City, UT, USA

IRF4/MUM1-POSITIVE B-CELL LYMPHOMA IN THE ABDOMEN AND RETROPERITONEUM Emily Mason. Vanderbilt University Medical Center, Nashville, TN, USA

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT Mariam Ratiani, Susan Olson , Marc Loriaux, Jennifer Dunlap, Todd Williams, Wei Xie, Phillip W. Raess. Oregon Health and Science University, Portland, OR, USA

LARGE B-CELL LYMPHOMA WITH IRF4 REARRANGEMENT Anu Rijal, Yi-Shan Lee. Washington University, St. Louis, MO, USA

IRF4 REARRANGED LARGE B CELL LYMPHOMA, PRESENTING AS A LARGE ABDOMINAL MASS. Ryan Sauls, Jinbo Fan, Ifeyinwa E Obiorah. University of Virginia Health system, Charlottesville, VA, USA

LARGE B-CELL LYMPHOMA WITH 11Q ABERRATION Thomas Tousseyn1, Lucienne Michaux2, Jolien De Bie2, Amber Verhasselt2, Geneviève Ameye2, Ann Janssens3. 1Dept of Pathology, Leuven, Belgium. 2Dept of Human Genetics, Leuven, Belgium. 3Dept of Hematology, Leuven, Belgium

FOUR-YEAR-OLD GIRL WITH RAPIDLY ENLARGING RIGHT CERVICAL LYMPH NODE Rakshit Tyagi, Joel Raqueno, Sheeja T. Pullarkat. Department of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

4:30 - 5:10 PM PLENARY LECTURE

LECTURE 7 Chairs: Robert Lorsbach, Thierry Molina Regency ABC

PRIMARY MEDIASTINAL B CELL LYMPHOMA: GENETICS, IMMUNE ESCAPE, BOUNDARIES Lisa Rimsza. University of Arizona, College of Medicine Tucson