WELCOMING REMARKS Michele Paessler.

NEW ENTITIES IN ACUTE LYMPHOBLASTIC LEUKEMIA Mike Borowitz. Johns Hopkins University

8:50

INTRODUCTION.

8:55

SCREENING FOR CD371 EXPRESSION FOLLOWED BY MULTI-MODAL CONFIRMATORY MOLECULAR TESTING ALLOWS RELIABLE DIAGNOSIS OF B-LYMPHOBLASTIC LEUKEMIA WITH DUX4 REARRANGEMENT Gordana Raca1, 2, Elizabeth Eom2, 3, Brent L. Wood1, 2, Alexandra E. Kovach1, 2. 1Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. 2Keck School of Medicine of University of California, Los Angeles, CA, USA. 3Hematology/Oncology, Department of Pediatrics, Los Angeles, CA, USA

9:07

B-ACUTE LYMPHOBLASTIC LEUKEMIA, BCR::ABL1-LIKE, JAK-STAT ACTIVATED OCCURRING IN DOWN'S SYNDROME Muhammad Moseeb Ali Hashim1, Soumya Mikkilineni2, Richard D. Hammer3. 1University Hospital, Columbia, MO, USA. 2University Hospital, Columbia, MO, USA. 3University Hospital, Columbia, MO, USA

9:19

T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH TLX3::BCL11B REARRANGEMENT: TOWARDS RECOGNITION OF A DISTINCT DIAGNOSTIC CATEGORY Rasha Alfattal, Beenu Thakral, Jie Xu, Sa A. Wang, Keyur P. Patel, Gokce A. Toruner, Andres E. Quesada. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

9:31

LEUKEMIA CUTIS IN AN ADOLESCENT WITH UBTF TANDEM DUPLICATION-ASSOCIATED AML Rohan Kodgule, Andrew Hughes, Eric Duncavage. Washington University in St. Louis, St Louis, MO, USA

9:43

PEDIATRIC PATIENT WITH ACUTE LEUKEMIA OF AMBIGUOUS LINEAGE (ALAL)/MIXED PHENOTYPE ACUTE LEUKEMIA (MPAL) WITH TCF3::ZNF384 FUSION Haluk Kavus, Andrew Campbell, Yi Ding, Mary Dhesi, Patrick Dorion. Geisinger Medical Center, Danville, PA, USA

9:55

CLINICAL AND MOLECULAR PERSPECTIVES ON A SMARCB1-DEFICIENT HEMATOLYMPHOID NEOPLASM ARISING SOLELY IN THE CENTRAL NERVOUS SYSTEM Sadhika Sood1, Caroline Christianson2, Carter Suryadevara3, Arnaldo Arbini1, Teresa Hidalgo3, Gloria Paz Contreras Yametti2, William Carroll2, Nicholas Ward1. 1Department of Pathology, New York University Grossman School of Medicine, New York City, NY, USA. 2Department of Pediatric Hematology-Oncology, New York University Grossman School of Medicine, New York City, NY, USA. 3Department of Neurosurgery, New York University Grossman School of Medicine, New York City, NY, USA

10:07

SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH ETV6:RUNX1 FUSION IN A 3-YEAR-OLD BOY Huma Asif, Anna B. Owczarczyk. Cleveland Clinic, Cleveland, OH, USA

A PATIENT WITH ROTHMUND-THOMPSON SYNDROME DEVELOPING ACUTE MYELOID LEUKEMIA Jayalakshmi Balakrishna. Roswell Park Cancer Center, Buffalo, NY, USA

EARLY T PRECURSOR LYMPHOBLASTIC LEUKEMIA WITH JAK1 MUTATION​ Alexandra M Balmaceda1, Giovanni Insuasti1, Nancy Rosenthal1, Michael Beaty1, Elizabeth Margolskee2. 1Wake Forest University School of Medicine Department of Pathology, Winston Salem, NC, USA. 2Children’s Hospital of Philadelphia/Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA

B/MYELOID MIXED-PHENOTYPE ACUTE LEUKEMIA WITH DUX4 AND RIN3 REARRANGEMENT Linnea S. Banker, Soumya Mikkilineni, Richard D. Hammer. University of Missouri, Columbia, MO, USA

B-LYMPHOBLASTIC LEUKEMIA WITH PAX5 P. P80R Basma Basha, Anica Wandler, Karen Chisholm, Sandra Bohling. Seattle Children's Hospital, Seattle, WA, USA

B-LYMPHOBLASTIC LEUKEMIA WITH PAX5 ALTERATION Basma Basha, Anica Wandler M. , Sandra Bohling D. , Karen Chisholm M. . Seattle Children's Hospital, Seattle, WA, USA

4-YEAR-OLD GIRL WITH CIRCULATING BLASTS Shelbey L. Bauman, Kelly A. Bowers, Megan O. Nakashima. Cleveland Clinic, Cleveland, OH, USA

MYELOID SARCOMA OF THE ORBIT ARISING IN AN INFANT WITH MOSAIC PARTIAL TRISOMY 18 Timothy M. Bell, Sarah L. Ondrejka, Megan O. Nakashima. Cleveland Clinic, Cleveland, OH, USA

DISSECTING A MULTILINEAGE PROCESS: 7-YEAR-OLD WITH EOSINOPHILIA Sarah Blain1, 2, Micheal Loken1, 3, Norman Lacayo4. 1Hematologics, Seattle, WA, USA. 2Université de Sherbrooke, Sherbrooke, QC, Canada. 3Fred Hutchinson Cancer Care, Seattle, WA, USA. 4Stanford Medicine Children’s Health, Los Gatos, CA, USA

A CHALLENGING CASE OF LEUKEMIA MRD : JOURNEY THROUGH THE UNCHARTED WATERS OF MPAL Sarah Blain1, 2, 3. 1HematoLogics, INC, Seattle, WA, USA. 2Prinses Maxima Centrum voor Kinderoncologie, Utrecht, Netherlands. 3Université de Sherbrooke, Sherbrooke, QC, Canada

MYELOID SARCOMA IN A PATIENT WITH MDS WITH FIBROSIS Sandra D. Bohling, Cate Paschal, Karen M. Chisholm. Seattle Children's Hospital, Seattle, WA, USA

T-LYMPHOBLASTIC LYMPHOMA IN A PATIENT WITH RING CHROMOSOME 14 SYNDROME John F. Brennan1, Dona Kanavy2, Jason Merker2, Ahren Rittershaus3, Danielle L. V. Maracaja1. 1University of North Carolina Medical Center, Chapel Hill, NC, USA. 2University of North Carolina Medical Center, Cytogenetics Laboratory, Chapel Hill, NC, USA. 3WakeMed Health & Hospitals, Raleigh, NC

B-LYMPHOBLASTIC LEUKEMIA WITH CRLF2 REARRANGEMENT AND EVIDENCE OF MONOCYTIC DIFFERENTIATION AT DIAGNOSIS: AN UNDERRECOGNIZED PHENOMENON OF UNCERTAIN SIGNIFICANCE  John B. Broussard1, Annie Luong2, Gerald Lu3, Michael Lu3, Chintan Parekh2, 4, 5, Gordana Raca3, 5, Brent L. Wood1, 5, Alexandra E. Kovach1, 5. 1Hematopathology, Children's Hospital Los Angeles, Los Angeles, CA, USA. 2Flow Cytometry Core, Children's Hospital Los Angeles, Los Angeles, CA, USA. 3Cytogenomics Laboratory, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. 4Hematology/Oncology, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, USA. 5Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

B LYMPHOBLASTIC LEUKEMIA WITH MATURE PHENOTYPE AND KMT2A::MLLT3 James R Cook, Meredith Nichols, Sheila Shurtleff. Cleveland Clinic, Cleveland, USA

BLASTIC MALIGNANCY OF UNCERTAIN LINEAGE, WITH DIAGNOSTIC GENETIC FINDINGS Anna Dar, Emily F. Mason. Vanderbilt University Medical Center, Nashville, TN, USA

ACUTE PROMYELOCYTIC LEUKEMIA PRESENTING AS MYELOID SARCOMA WITHOUT BONE MARROW INVOLVEMENT Luiz Paulo De Lima Guido, Jennifer R Chapman. University of Miami, Miami, FL, USA

ACUTE MYELOID LEUKEMIA WITH NPM1::MLF1 REARRANGEMENT Ismail Elbaz Younes, Sophia Yohe, Amy K Beckman, Michael Linden, Cade Arries, Samreen Fathima, Mehrnoosh Tashakori. Department of Laboratory Medicine and Pathology, Minneapolis, MN, USA

MYELOID SARCOMA ASSOCIATED WITH ACUTE MYELOID LEUKEMIA WITH DEK::NUP214 FUSION Giby V George, Malgorzata Kajstura, W Richard Burack, Andrew G Evans, Hibbah B Nabeel, Chauncey R Syposs. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA

DONOR-DERIVED MYELOID NEOPLASM WITH GATA1 AND FANCA VARIANTS: A RARE AND COMPLEX CASE ARISING IN A YOUNG PATIENT POST-UMBILICAL CORD BLOOD TRANSPLANT Ruth Gichinga, Kirill Karlin, Loren Joseph, Robert Willim. Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA

A TALE OF TWO KIDNEYS: DONOR-DERIVED B-LYMPHOBLASTIC LYMPHOMA ARISING IN A TRANSPLANTED KIDNEY Mary A Hansen Smith1, Jose Hector Elizondo Jasso1, 2, Meifang Wu1, Joshua Greenwald1, 4, Rachel Lestz3, 4, Jaime Stokke4, 5, Rebecca Kelly5, Caleb Cornaby1, 4, Jocelyn San Miguel4, Arsineh Karabedian4, Lee Ann Baxter-Lowe1, 4, Bruce Pawel1, 4, Jaclyn Biegel1, 4, Gordana Raca1, 4, Alexandra E Kovach1, 4. 1Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, CA, USA. 2 Department of Anatomic Pathology and Cytopathology, University Hospital, Monterrey, Mexico. 3Nephrology, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, USA. 4Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. 5Hematology/Oncology, Department of Pediatrics, Children’s Hospital Los Angeles, Los Angeles, CA, USA

AN UNUSUAL PRESENTATION OF ACUTE MYELOID LEUKEMIA WITH KMT2A REARRANGEMENT IN A PEDIATRIC PATIENT Moinul Haque1, Alexa Siddon1, Jiadi Wen2, Mina Xu1, Krasimira Rozenova1. 1Departments of Pathology and Laboratory Medicine, Yale University, New Haven, CT, USA. 2Department of Genetics, Yale University, New Haven, CT, USA

B-ALL WITH IKZF1 N159Y MUTATION Matthew Koo, Anamaria Munteanu, Niroshi Senaratne, Sung-Hae Kang. UCLA, Los Angeles, CA, USA

ACUTE MYELOID LEUKEMIA WITH BASOPHILIA AND STAT5B MUTATION Priya Kumar, Paul Mead, Patrick Blackburn, Corey Xu, Lu Wang, Jeffery Klco, Vidya Balgopal. St Jude Children's Research Program, Memphis, TN, USA

A CASE OF B-ACUTE LYMPHOBLASTIC LEUKEMIA WITH HLF REARRANGEMENT Jingwei Li, David Grier, Teresa Smolarek, Jonathan Dillman, Robert Lorsbach. Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH ETV6::RUNX1-LIKE FEATURES Yen-Chun Liu, Jeffery Klco, Lu Wang. St. Jude Children's Research Hospital, Memphis, TN, USA

ACUTE MYELOID LEUKEMIA WITH MYELODYSPLASIA-RELATED GENE MUTATIONS (ICC2022) ACUTE MYELOID LEUKAEMIA, MYELODYSPLASIA-RELATED (WHO-HAEM5) Rachel A Mariani1, 2. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA

B-ALL WITH ETV6::RUNX1-LIKE FEATURES AND CD27-/CD44+ Rachel A Mariani1, 2, Bo Hong3, 4. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. 3ARUP Laboratories, Salt Lake City, UT, USA. 4University of Utah, Salt Lake City, UT, USA

MYELOID SARCOMA WITH KMT2A-REARRANGEMENT INVOLVING CENTRAL NERVOUS SYSTEM AND SKELETAL MUSCLE Rachel A. Mariani1, 2, Melissa F. Stalling3. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. 3Akron Children's Hospital, Akron, OH, USA

MALIGNANT HEMATOPOIETIC NEOPLASM WITH INI-1 DEFICIENCY - AN AGGRESSIVE NOVEL FORM OF T-CELL LYMPHOMA IN YOUNG PATIENTS Nadia Nasir1, Joao V. Alves de Castro1, Eduard Matkovic2, Erica F. Reinig2, Daniel J. Robbins2, Daniel R. Matson2, 3, Christina Amend2, Allison M. Weisnicht2, Hao-Wei Wang1, Mark Raffeld1, Stefania Pittaluga1, Elaine S. Jaffe1. 1National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2University of Wisconsin-Madison, Madison, WI, USA. 3Wisconsin Blood Cancer Research Institute, Madison, WI, USA

MEDIASTINAL MYELOID SARCOMA WITH A RARE RECURRING TRANSLOCATION  Sarah L. Ondrejka1, Melissa Stalling 2, Matthew Keisling2. 1Cleveland Clinic, Cleveland, OH, USA. 2Akron Children's Hospital, Akron, OH, USA

MYELOID SARCOMA AS INITIAL PRESENTATION Mary Peeples, Gratian Salaru, Richard Drachtman, Payal Sojitra. Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA

ACUTE MYELOID LEUKEMIA WITH MEGAKARYOBLASTIC/ ERYTHROBLASTIC DIFFERENTIATION AND WITH PICALM::MLLT10 FUSION.   Kseniya Petrova-Drus1, 2, Umut Aypar3, Jinjuan Yao2, Jamal Benhamida3, Yanming Zhang3, Mikhail Roshal1. 1Hematopathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2Diagnostic Molecular Pathology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 3Cytogenetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA

T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA, GAMMA DELTA TYPE WITH UNUSUAL IMMUNOPHENOTYPE AND FUSIONS IN ABL1 AND NUP214 GENES You-Wen Qian1, Lalarukh Aftab2, Mihai Merzianu1, Matthew Barth1, Adrian Dubuc 1. 1Roswell Park Cancer Center, Buffalo, NY, USA. 2University at Buffalo, Buffalo, NY, USA

MYELOID NEOPLASM POST CYTOTOXIC THERAPY (MN-PCTS) 6 YEARS AFTER BONE MARROW TRANSPLANT FOR SICKLE CELL DISEASE (SCD Wafa M Sarraj1, Shaheen Malick1, Monika Pilichowska1, Christopher G Kanakry2, Courtney Fitzhugh2. 1Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA, USA. 2Center for Cancer Research, National Cancer Institute (NIH), Bethesda, MD, USA

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH HIGH HYPERDIPLOIDY AND KAT6A::NCOA2 FUSION Neha Seth1, Pallavi Khattar1, Gervita Singh2, Morris C Edelman1, Ram Singh1, Pratik Q. Deb1, Silvat Sheikh-Fayyaz1. 1Long Island Jewish Medical Center/North Shore University Hospital, Northwell Health, New York, NY, USA. 2Stuyvesant High School, New York, NY, USA

B-LYMPHOBLASTIC LYMPHOMA WITH MATURE PHENOTYPE AND KMT2A REARRANGEMENT  - A DIAGNOSTIC DILEMMA AND UNIQUE ENTITY Audi F Setiadi1, 2, Christine Tyson1, 2, Neval Ozkaya2, 3, Christof Senger1, 2, Caron Strahlendorf2, 4. 1BC Children's Hospital Department of Pathology and Laboratory Medicine, Vancouver, BC, Canada. 2University of British Columbia, Vancouver, BC, Canada. 3BC Cancer Agency, Vancouver, BC, Canada. 4BC Children's Hospital Division of Hematology and Oncology, Department of Pediatrics, Vancouver, BC, Canada

ACUTE MYELOID LEUKEMIA WITH T(9;11)KMT2A::MLLT3 FUSION PRESENTS WITH TESTICULAR MYELOID SARCOMA WITH MONOCYTIC DIFFERENTIATION Ping Shi, Eman Sallam, Erik Washburn, Michael G. Bayerl. Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA

B-LYMPHOBLASTIC LYMPHOMA PRESENTING AS A SOLITARY RENAL MASS WITH EWSR1::FLI1 TRANSLOCATION AND CHEK2 MISSENSE MUTATION Jonathan Sookdeo1, Katelyn Purvis2, Mohammad Eldomery3, Gabriela Gheorghe3. 1University of Tennessee Health Science Center, Department of Pathology and Laboratory Medicine, Memphis, TN, USA. 2St Jude Children's Research Hospital, Department of Pediatric Hematology-Oncology, Memphis, TN, USA. 3St Jude Children's Research Hospital, Department of Pathology, Memphis, TN, USA

ACUTE BASOPHILIC LEUKEMIA WITH ETV6::HCK PRESENTING AS A PAROTID GLAND MASS Melissa Stalling1, Brittany Ewing2, Matthew Leffew2, Shweta Bhavsar3, Vanisha Patel1, Michael Loken4. 1Akron Children's Hospital, Akron, OH, USA. 2Summa Health System, Akron, OH, USA. 3Cleveland Clinic, Cleveland, OH, USA. 4Hematologics, Inc, Seattle, WA, USA

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH PAX5 ALTERATION  Melissa Stalling1, Mark Steele1, Jie Xu1, Shweta Bhavsar2, Matthew Leffew3. 1Akron Children's Hospital, Akron, OH, USA. 2Cleveland Clinic, Cleveland, OH, USA. 3Summa Health System, Akron, OH, USA

“ASYMPTOMATIC” PEDIATRIC T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH KMT2A REARRANGEMENT Mark Strong, Navitha Woddor, Akif Guney, Nicholas Ward, Christopher Park, Arnaldo Arbini, Xiaoyan Huang. New York University Langone Health, New York, NY, USA

PEDIATRIC B-LYMPHOBLASTIC LEUKEMIA WITH A RARE TYPE OF BCR-ABL TRANSCRIPT B2A3(E13A3) AND MULTILINEAGE INVOLVEMENT Mark Strong, Navitha Woddor, Akif Guney, Sotirios F Karathanasis, Tatyana Gindin, Shashi Pawar, Nicholas Ward, Christopher Park, Arnaldo Arbini, Xiaoyan Huang. New York University Langone Health, New York, NY, USA

ACUTE MYELOD LEUKEMIA IN THE SETTING OF DOWN SYNDROME Ravina D. Thuraisingam, Candace Y. Reveles. University of Arizona, Tucson, AZ, USA

THE JOURNEY OF CLASSIFYING A CHALLENGING LEUKEMIA: A DIAGNOSTIC DILEMMA Parastou Tizro, Karl Gaal, Young Kim, Michelle Afkhami, Leila Youssefian, Winston Lee, Joo Song, Lorinda Soma. City of Hope, Duarte, CA, USA

CASE OF ACUTE MYELOID LEUKEMIA WITH T(8;16) KAT6A::CREBBP FUSION, THERAPY-RELATED Jayalakshmi Venkateswaran, Mingfei Yan, Leonardo Boiocchi, Yanming Zhang, Ahmet Dogan. Memorial Sloan Kettering Cancer Center, New York, NY, USA

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA WITH MYC REARRANGEMENT Anjanaa Vijayanarayanan, Sonam Prakash, Karthik Ganapathi. University of California, San Francisco, CA, USA

B-LYMPHOBLASTIC LEUKEMIA WITH P2RY8::CRLF2 GENE FUSION IN A PATIENT WITH DOWN SYNDROME Vorapat Vorapanya1, Alisha Ware1, 2, Danielle L. V. Maracaja1. 1University of North Carolina, Chapel Hill, NC, USA. 2John Hopkins University, Baltimore, MD, USA

MARROW INVELOVEMENT BY ACUTE MYELOMONOCYTIC LEUKEMIA WITH INV (16) (P13. 1Q22)/CBFB::MYH11 Peter Wanes, Anindita Ghosh, Tariq Muzzafar, Guilin Tang, Zhuang Zuo, Gokce Tourner, Keyur Patel, Chi Y Ok, Fatima Z Jelloul, Sofia Garces, Vasiliki Leventaki, Cesar Nunez, Carlos Bueso-Ramos. MD Anderson Cancer center, Houston, TX, USA

IDENTIFICATION OF MEF2D::FOXJ2 FUSION AND CHROMOANAGENESIS IN B-ALL USING OPTICAL GENOME MAPPING Qing Wei, Carols E. Bueso-Ramos, L. Jeffrey Medeiros, Guilin Tang. MD Anderson Cancer Center, Houston, TX, USA

B-ALL WITH ZNF384-LIKE REARRANGMENT AND IKZF1-PLUS: A CASE HIGHLIGHTING A ROLE FOR OPTICAL GENOME MAPPING Qing Wei, Carols E. Bueso-Ramos , L. Jeffrey Medeiros, Guilin Tang. MD Anderson Cancer Center, Houston, TX, USA

B-LYMPHOBLASTIC LYMPHOMA WITH TP53 MUTATION PRESENTING AS A SOFT TISSUE MASS Sarah J. Wu1, Katelynn M. Wilton1, Evan Chen2, Scott Ryall1, Anne Giersch1, Harrison Tsai1, Valentina Nardi1, Scott Rodig1, Sam Sadigh1. 1Brigham and Women's Hospital, Boston, MA, USA. 2Dana Farber Cancer Institute, Boston, MA, USA

14-YEAR-OLD MAN WITH AGGRESSIVE HEMATOPOIETIC NEOPLASM WITH BIALLELIC LOSS OF SMARCB1, PRESENTING MYELOID, B-CELL, AND T/NK-CELL DIFFERENTIATION.     Mariko Yabe1, Kseniya Petrova-Drus1, 2, Jamal Benhamida2, Ahmet Dogan1. 1Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. 2Diagnostic Molecular Pathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

ACUTE ERYTHROID LEUKEMIA WITH CIC REARRANGEMENT IN A NEWBORN Sheren Younes, Alexandra Chang-Graham, Jean Oak , Thien Phuc Dac Nguyen Nguyen, Tanja Gruber, Oscar Silva. Stanford University, Stanford, CA, USA

B-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA (B-ALL/LBL) WITH MASKED NEAR-HAPLOIDY PRESENTING WITH SEVERE EOSINOPHILIA Mariam Youssef, Navitha Woddor, Shashi Pawar, Christopher Park. NYU Grossman School of Medicine, New York, NY, USA

MYELOID SARCOMA RELAPSE FROM ACUTE MYELOID LEUKEMIA WITH KMT2A REARRANGEMENT AND MUTATED TP53. Nives Zimmermann, Anna Balog, Youssef Khafateh. University of Cincinnati, Cincinnati, OH, USA

MYELOID MALIGNANCIES AND TRISOMY 21: TRANSIENT ABNORMAL MYELOPOIESIS AND MYELOID LEUKEMIA OF DOWN SYNDROME Johann (Hans) Hitzler. The Hospital for Sick Children

11:30

INTRODUCTION.

11:35

MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME PRESENTING AFTER A PROLONGED “PRE-LEUKEMIC” PHASE Benjamin Kaumeyer1, 2, Kristina Brannock1, 2, Kathleen Nicol1, 2, Samir Kahwash1, 2. 1Nationwide Children's Hospital, Columbus, OH, USA. 2The Ohio State University, Department of Pathology, Columbus, OH, USA

11:47

GERMLINE GATA1S-ASSOCIATED PEDIATRIC ACUTE MEGAKARYOBLASTIC LEUKEMIA Yong Zhang1, 2, Emily Harris3, Alan Cantor3, Marian H. Harris1, Mark Fleming1, Jacob R. Bledsoe1. 1Department of Pathology, Boston Children's Hospital, Boston, MA, USA. 2Department of Pathology, Mass General Brigham, Boston, MA, USA. 3Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA

11:59

ACUTE MEGAKARYOBLASTIC LEUKEMIA IN A PEDIATRIC DOWN SYNDROME PATIENT WITH GATA1 WILD TYPE Grant Kozeny1, 2, William P. Morrow1, 2, Danielle Maracaja3. 1Atrium Heath Wake Forest Baptist Medical Center, Winston-Salem, NC, USA. 2Wake Forest University School of Medicine, Winston-Salem, NC, USA. 3University of North Carolina, Chapel Hill, NC, USA

12:11

ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH NUP98::KDM5A FUSION AND HOMOZYGOUS DELETION OF CDKN2A/B IN A 3-YEAR-OLD  Nagehan Pakasticali, Jesse Jaso , Olga Weinberg, Weina Chen, Miguel D. Cantu. University of Texas Southwestern, Dallas, TX, USA

12:23

A CASE OF THERAPY RESISTANT AML/RAM VARIANT Samir Kahwash, Kathleen Nicol, Kristina Brannock, Benjamin Kaumeyer. Nationwide Children, Columbus, OH, USA

12:35

MYELOID SARCOMA WITH ERYTHROID DIFFERENTIATION AND NFIA::CBFA2T3 REARRANGEMENT. Rabail Aslam1, Pedro Ciarlini1, Shashirekha Shetty2, Kwadwo Oduro3, Howard Meyerson1. 1Department of Pathology, Hematopathology Division, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. 2Cytogenetics Laboratory, Center of Human Genetics Laboratory, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. 3Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

12:47

SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

UNEXPECTED ADVERSE CLINICAL OUTCOME IN A NEW-BORN WITH DOWN SYNDROME PRESENTING WITH TRANSIENT MYELOPROLIFERATIVE DISORDER. Ahmed Arfa1, ling zhang1, Johnny Nguyen 2. 1Department of Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA. 2Department of Pathology, Johns Hopkins All Children’s Hospital, Tampa, FL, USA

CONCOMITANT DEL(7Q) AND INV(16) IN A 20-MONTH-OLD WITH AML Timothy M. Bell, Heesun Joyce Rogers, Genevieve M. Crane. Cleveland Clinic, Cleveland, OH, USA

RAM PHENOTYPE ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH CBFA2T3::GLIS2 FUSION Hariharan S. Bharadwaj1, 2, Jacob Bledsoe1. 1Boston Children's Hospital, Boston, MA, USA. 2Brigham & Women's Hospital, Boston, MA, USA

ACUTE MYELOID LEUKEMIA WITH CBFA2T3::GLIS2 FUSION PRESENTING AS A PARASPINAL MASS Sandra D. Bohling, Anica M. Wandler, Karen M. Chisholm. Seattle Children's Hospital, Seattle, WA, USA

NFIA-RUNX1T1 TRANSLOCATION IN AN INFANT ERYTHROBLASTIC SARCOMA: A NOVEL ENTITY Chuan Chen, Kaaren K. Reichard, Rebecca L. King. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

DE-NOVO ACUTE MYELOID LEUKEMIA WITH LOSS OF 19Q13. 1 AND CSF3R MUTATION IN ADOLESCENT PATIENT WITH DOWN SYNDROME Kenn Chen, Alireza Torabi. University of Washington, Seattle, WA, USA

A RARE PEDIATRIC CASE OF ACUTE MYELOID LEUKEMIA WITH UNUSUAL MORPHOLOGICAL AND IMMUNOPHENOTYPIC FEATURES AND NPM1::CCDC3 FUSION Jason Cheng, Peng Wang. University of Chicago, Chicago, IL, USA

MYELOID NEOPLASM ASSOCIATED WITH DOWN SYNDROME PRESENTING AS A RETROPERITONEAL MASS IN A 5-YEAR-OLD  Karen M Chisholm, Sandra D. Bohling. Seattle Children's Hospital, Seattle, WA, USA

ACUTE MYELOID LEUKEMIA WITH NUP98-REARRANGEMENT April Chiu, Xinjie Xu, Kaaren Reichard. Mayo Clinic, Rochester, MN, USA

ACUTE MEGAKARYOBLASTIC LEUKAEMIA IN 2 YEAR-OLD BOY WITH TRISOMY 21 RESTRICTED TO THE LEUKEMIC CLONE, SUBSEQUENT TP53 MUTATION AND AGGRESSIVE COURSE Genevieve M Crane, Heesun J Rogers. Cleveland Clinic, Cleveland, OH, USA

MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNBDROME IN A 19-MONTH-OLD CHILD WITH THROMBOCYTOPENIA Brianna Cuniff, Michelle Dolan, Ismail Elbaz Younes, Betsy Hirsch, Jennifer Laffin, Michael A Linden, Andrew C. Nelson, Mehrnoosh Tashakori, Amy K. Beckman. University of Minnesota Medical School, Minneapolis, MN, USA

KMT2A PARTIAL TANDEM DUPLICATION IN PEDIATRIC ACUTE MYELOID LEUKEMIA PRESENTING WITH DYSPLASIA Eric Duncavage, David Spencer, Yi Shan Lee, Cara Shari, Mariana Ruzinova. Washington University, St. Louis, MO, USA

ACUTE MYELOID LEUKEMIA WITH NUP98 REARRANGEMENT AND SUBCLONAL CYTOGENETIC AND MOLECULAR VARIANTS FOLLOWING RELAPSE Giby V George, Malgorzata Kajstura, W Richard Burack, Andrew G Evans, Hibbah B Nabeel, Chauncey R Syposs. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA

EVOLVING ACUTE LEUKEMIA WITH MYELOID AND T-LINEAGE FEATURES AFTER BONE MARROW TRANSPLANT IN A PATIENT WITH HUNTER SYNDROME Ellie Hong1, Majd Jawad1, 2, Ahmad Al-Attar1, 2, Nidhi Aggarwal1, 2, Colleen Matthews1, 2, Sara Monaghan1, 2, Erika Moore1, 2, Katelynn Davis1, 2. 1University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 2University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

INFANT ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH RARE NUP98 REARRANGEMENT Darrell Horton, Andres Mindiola Romero, Daniel Babu. University of New Mexico Health Sciences Center, Albuquerque, NM, USA

ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH GATA1 MUTATION Jeffrey R Jacobsen1, Rodney R Miles1, Kristi J Smock1, Melissa H Cessna2, Lesli Dewyze2, Ann Taylor2. 1University of Utah and ARUP Laboratories, Salt Lake City, UT, USA. 2Intermountain Medical Center, Murray, UT, USA

MYELOID NEOPLASM WITH DOUBLE MINUTE REPEATS AND CMYC AMPLIFICATION IN AN INFANT Jeffrey R Jacobsen, Rodney R Miles, Timothy M Hanley, Erica F Andersen, Bo Hong, Jian Zhao. University of Utah Department of Pathology and ARUP Laboratories, Salt Lake City, UT, USA

MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME Alexandra E Kovach1, 2, John Broussard1, Karen Kim3, Paul Gaynon2, 3, Elizabeth Eom2, 3, Etan Orgel2, 3, Gordana Raca1, 2. 1Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. 2Keck School of Medicine of University of California, Los Angeles, CA, USA. 3Hematology/Oncology, Department of Pediatrics, Los Angeles, CA, USA

INFANTILE AML WITH MIXED MEGAKARYOCYTIC AND ERYTHROID DIFFERENTIATION AND T(X;6) SUGGESTING GATA1/MYB1 FUSION Chandra Krishnan1, 2. 1Dell Children's Medical Center, Austin, TX, USA. 2University of Texas, Dell Medical School, Austin, TX, USA

UNUSUAL CONCURRENT NEOPLASMS INFANTILE AML WITH MLLT10/KMT2A FUSION AND NEUROBLASTOMA, DIFFERENTIATING WITHOUT MYCN AMPLIFICATION Chandra Krishnan1, 2, George Huang1. 1University of Texas, Dell Medical School, Austin, TX, USA. 2Dell Children's Medical Center, Austin, TX, USA

NEONATAL ACUTE MYELOID LEUKEMIA WITH MYB::GATA1 Priya Kumar, Paul Mead, Nishi Harwani, Hiroto Inaba, Patrick Blackburn, Lulu Wang, Masayuki Umeda, Jeffery Klco, Mahsa Khanlari, Yen-Chun Liu. St Jude Children's Research Hospital, Memphis, TN, USA

INFANT AML WITH KAT6B::NUTM2B FUSION Yen-Chun Liu1, Mahsa Khanlari1, La'Ron Browne2, Seth Karol2, Jeffery Klco1, Lu Wang1. 1St. Jude Children's Research Hospital, Department of Pathology, Memphis, TN, USA. 2St. Jude Children's Research Hospital, Department of Oncology, Memphis, TN, USA

PEDIATRIC ACUTE MYELOID LEUKAEMIA (AML) WITH NUP98 REARRANGEMENT Nicolas Lopez-Hisijos, Megan Smith. Vanderbilt University Medical Center, Nashville, TN, USA

ACUTE MYELOID LEUKEMIA WITH OTHER DEFINED GENETIC ALTERATIONS: CBFA2T3::GLIS2 FUSION (AND “RAM IMMUNOPHENOTYPE”) (WHO-HAEM5) Rachel Mariani1, 2, Melissa Stalling3. 1Phoenix Children's Hospital, Division of Pathology and Laboratory Medicine, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. 3Akron Children's Hospital, Akron, OH, USA

ACUTE MYELOID LEUKEMIA WITH NUP98-REARRANGEMENT (WHO-HAEM5)/NUP98 AND OTHER PARTNERS (ICC2022) WITH CLONAL EVOLUTION AND LINEAGE SWITCH TO MIXED-PHENOTYPE ACUTE LEUKEMIA, B/MYELOID Rachel A Mariani1, 2. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA

CHARACTERISTIC BLAST MORPHOLOGY AND IMMUNOPHENOTYPE ASSIST IN IDENTIFICATION OF TRISOMY 21 IN A SETTING OF LIMITED PRENATAL CARE Margaret Moore, Elizabeth Courville, Jeffrey Craig, Nadine Aguilera. University of Virginia Health, Charlottesville, VA, USA

ACUTE MYELOID LEUKEMIA WITH MEGAKARYOBLASTIC DIFFERENTIATION AND RBM15-MKL1 FUSION IN A 21 MONTHS OLD GIRL Oluwole Odujoko, Mingfei Yan, Leonardo Boiocchi, Shenon Sethi, Vanderbilt Chad, Umut Aypar, Alexander Chan, Yanming Zhang. Memorial Sloan-Kettering Cancer Center, New-York city, NY, USA

UNIQUE FEATURES OF MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME (ML-DS) Aviv Oren, Sumire Kitahara. Cedar Sinai Medical Center, Los Angeles, CA, USA

ACUTE MYELOID LEUKEMIA WITH NUP98 REARRANGEMENT Alma R Oskarsdottir, Xinjie Xu, Kaaren K Reichard. Mayo Clinic, Rochester, MN, USA

ACUTE MEGAKARYOBLASTIC LEUKEMIA (FAB M7) WITH KMT2A::MLLT10 FUSION Xenia Parisi, Shimin Hu, Gokce Toruner, Ellen Schlette. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

LINEAGE SWITCH OF PRE-B-ACUTE LYMPHOBLASTIC LEUKEMIA WITH KMT2A::AFF1 FUSION INTO ACUTE MYELOMONOCYTIC LEUKEMIA​ Xenia Parisi, Anindita Ghosh, Guilin Tang, Jeffrey L. Jorgensen. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

ACUTE MEGAKARYOBLASTIC LEUKEMIA ASSOCIATED WITH DOWN SYNDROME Pranav Patwardhan1, Steven Allen1, 2, Ahmad Al-Attar1, 2, Majd Jawad1, 2, Flavia Rosado3, Katelynn Davis1, 2. 1University of Pittsburgh Medical Center, Pittsburgh, PA, USA. 2University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 3Butler Memorial Hospital, Butler, PA, USA

ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH CBFA2T3::GLIS2 FUSION IN A NEUROBLASTOMA STAGING BONE MARROW Pranav Patwardhan, Laura Molina, Ahmad Al-Attar, Kelly Bailey, Erika Friehling, Catherine Gestrich, Nidhi Aggarwal, Majd Jawad, Nathanael Bailey, Katelynn Davis. University of Pittsburgh Medical Center, Pittsburgh, PA, USA

ACUTE MEGAKARYOBLASTIC LEUKEMIA WITH RBM15-MKL1 Elizabeth Pogue, Adam Seegmiller, Ashwini Yenamandra, Emily F. Mason. Vanderbilt University Medical Center, Nashville, TN, USA

KMT2A-REARRANGED ACUTE MEGAKARYOBLASTIC LEUKEMIA MIMICKING ATYPICAL LYMPHOCYTOSIS AND IDIOPATHIC THROMBOCYTOPENIC PURPURA  Lianqun Qiu, Guilin Tang, Tariq Muzzafar, L. Jeffrey Medeiros, Carlos Bueso-Ramos, Beenu Thakral. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

2-YEAR-OLD WITH ACUTE MYELOID LEUKEMIA WITH NUP98 REARRANGEMENT/ ACUTE ERYTHROID LEUKEMIA Aida Richardson1, 2. 1Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA. 2Northwestern University, Chicago, IL, USA

THE HIDDEN FUSION IN AML - WHEN FISH MISSES AND SEQUENCING DELIVERS Neha Seth, Pallavi Khattar, Ram Singh, Wayne Tam, Pratik Q Deb. Long Island Jewish Medical Center/North Shore University Hospital, Northwell Health, New York, NY, USA

ACUTE MYELOID LEUKEMIA, RAM PHENOTYPE WITH CBFA2T3/GLIS2 TRANSLOCATION Mayuri Shende, Scott Turner, Rajeswari Jayakumar. Virginia commonwealth university, Richmond, VA, USA

MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME YUAN SHUI, Weibo Yu, Sheeja Pullarkat. David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

PURE ERYTHROID SARCOMA OF THE CNS Sam Sirotnikov1, Gerald Wertheim2. 1Children's National Hospital, Washington, DC, USA. 2Children's Hospital of Philadelphia, Philadelphia, PA, USA

MYELOID LEUKEMIA ASSOCIATED WITH DOWN SYNDROME WITH AN UNCOMMON TERTIARY MUTATION JAK2 V617I  Mehrnoosh Tashakori, Michael A. Linden, Pawel Mroz, Betsy Hirsch, Michelle Dolan. Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA

ACUTE LEUKEMIA WITH KMT2A REARRANGEMENT AND PLASMACYTOID DENDRITIC CELL IMMUNOPHENOTYPE Alireza Torabi1, Ryan Morse1, Jonathan Fromm1. 1University of Washington, seattle, WA, USA. 2University of Washington, seattle, WA, USA. 3University of Washington, seattle, WA, USA

BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - LIKE PHENOTYPE IN ACUTE MYELOID LEUKEMIA WITH T(9;11)(P12;Q23)/KMT2A::MLLT3 REARRANGEMENT Carlos J Villarroel1, 2, Maria A Proytcheva1, 2. 1University of Arizona College of Medicine -Tucson, Department of Pathology and Laboratory Medicine, Tucson, AZ, USA. 2Banner University Medical Center-Tucson, Tucson, AZ, USA

UNUSUAL PRESENTATION OF ACUTE MYELOID LEUKEMIA WITH KMT2A REARRANGEMENT Ritika Walia1, Sindhu cherian1, Teresa Hyun1, 2, Xueyan Chen1, 2. 1University of Washington, Seattle, WA, USA. 2Fred Hutch Cancer Center, Seattle, WA, USA

TRANSIENT ABNORMAL MYELOPOIESIS IN A NEWBORN WITH DOWN SYNDROME Scott Kuan-Wen Wang, Antonella Pallante, Laila Mnayer, Joseph DiGiuseppe. Hartford Hospital, Hartford, CT, USA

ACUTE MYELOID LEUKEMIA WITH NUP98::NSD1 FUSION Geoffrey D Wool, Angela Lager, Peng Wang. University of Chicago, Department of Pathology, Chicago, IL, USA

AN 18-YEAR-OLD GIRL PRESENTING WITH SEVERE PANCYTOPENIA Weibo Yu, Yuan Shui, Tharanga Senaratne, Sheeja Pullarkat. University of california, Los Angeles, Los Angeles, CA, USA

ACUTE ERYTHROID LEUKAEMIA OF AN INFANT PRESENTING WITH CHLOROMA. Seher Yuksel1, Arzu Saglam Ayhan2, Klara Dalva3, Hasan Fatih Cakmakli4, Mehmet Ertem4, isinsu Kuzu1. 1Ankara Unversty Faculty of Medicine Dept of Pathology, Ankara, Turkey. 2Hacettepe Unversty Faculty of Medicine, Dept of Pathology, Ankara, Turkey. 3Ankara Unversty Faculty of Medicine, Dept of Hematology, Ankara, Turkey. 4Ankara Unversty Faculty of Medicine, Pediatric Hematology, Ankara, Turkey

JUVENILE MYELOMONOCYTIC LEUKEMIA: FROM MONOCYTES TO GENETICS AND CLASSIFICATION Charlotte Niemeyer. University Medical Center Freiburg

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INTRODUCTION.

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NOONAN SYNDROME WITH MUTATED KRAS Rohit Gulati1, Nives Zimmerman2, Magdalena Czader1. 1Indiana University School of Medicine, Indianapolis, IN, USA. 2University of Cincinnati, Cincinnati, OH, USA

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JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) WITH MULTIPLE ACQUIRED SOMATIC MUTATIONS INCLUDING KRAS AND NOVEL ETV6 MUTATION Kristina R Brannock1, 2, Benjamin Kaumeyer1, 2, Samir Kahwash1, 2, Kathleen Nicol1, 2. 1Nationwide Children's Hospital, Columbus, OH, USA. 2Ohio State University Wexner Medical Center, Columbus, OH, USA

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JUVENILE MYELOMONOCYTIC LEUKEMIA IN A CHILD WITH SEVERE CONGENITAL NEUTROPENIA Adam C. Seegmiller. Vanderbilt University Medical Center, Nashville, TN, USA

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MYELOPROLIFERATIVE NEOPLASM WITH NO DRIVER MUTATION Monika Klimkowska. Karolinska University Hospital, Stockholm, Sweden

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MYELOID/LYMPHOID NEOPLASM WITH PDGFRA REARRANGEMENT Brent E. Harbaugh1, 2, Soumya Pandey1, 2. 1University of Arkansas for Medical Sciences, Little Rock, AR, USA. 2Arkansas Children's Hospital, Little Rock, AR, USA

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PEDIATRIC SYSTEMIC MASTOCYTOSIS Irina Maric, Xiaoping Sun, Melody Carter. National Institutes of Health, Bethesda, MD, USA

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SUMMARY OF SUBMITTED CASES IN THIS CATEGORY.

A CASE OF CHILD WITH JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) LIKE WITHOUT RAS-PATHWAY MUTATIONS Ahmad Alshomrani1, Katherine Calvo 2. 1National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. 2 Clinical Center, National Institutes of Health, Bethesda, MD, USA

JUVENILE MYELOMONOCYTIC LEUKEMIA-LIKE NEOPLASM WITH RANBP2::ALK AND MONOSOMY 7 Daniel Arber1, Sandeep Gurbuxani1, Angela Lager1, Girish Venkataraman1, Peng Wang1, Yanxia Li2. 1University of Chicago, Chicago, IL, USA. 2Advocate Christ Medical Center, Oak Lawn, IL, USA

JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) IN A 3-YEAR-OLD BOY WITH GERMLINE PTPN11 MUTATION WITHOUT NOONAN SYNDROME Chao Chen, Sheeja T. Pullarkat. Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los angeles, CA, USA

JUVENILLE MYELOMONOCYTIC LEUKEMIA WITH ASSOCIATED INDOLENT T LYMPHOBLASTIC PROLIFERATION James R Cook. Cleveland Clinic, Cleveland, OH, USA

JUVENILE MYELOMONOCYTIC LEUKEMIA WITH SOMATIC PTPN11 MUTATION Magdalena Czader, Rohit Gulati, Kavita Umrau. Indiana University, Indianapolis, IN, USA

JUVENILE MYELOMONOCYTIC LEUKEMIA IN A PATIENT WITH A GERMLINE NF1 MUTATION Melissa C Delio, Mina Xu. Yale University, New Haven, CT, USA

JUVENILE MYELOMONOCYTIC LEUKEMIA WITH RRAS2 MUTATION Anam Hamid, Jennifer Dunlap, Wei Xie. Oregon Health & Science University, Portland, OR, USA

ATYPICAL MEGAKARYOCYTES MASQUERADING AS A MYELOPROLIFERATIVE NEOPLASM. Matan Kadosh1, Alina Dulau Florea2, Amy Duffield2, Christian Salib2. 1Icahn School of Medicine at Mount Sinai, Mount Sinai West Hospital, New York, NY, USA. 2Icahn Medicine at Mount Sinai, Mount Sinai Hospital, New York, NY, USA

CHRONIC MYELOID LEUKEMIA DISGUISED AS TOXICITY SECONDARY TO MULTIPLE PSYCHIATRIC MEDICATIONS Justin Kelley. Vanderbilt University Medical Center, Nashville, TN, USA

THROMBOCYTOSIS AND MEGAKARYOCYTIC PROLIFERATION, MPN OR NOT? Monika Klimkowska. Karolinska University Hospital, Stockholm, Sweden

DIAGNOSIS OF A RARE DISORDER IN A 3-YEAR-OLD FEMALE WITH CHRONIC PANCYTOPENIA Brian Lockhart1, Gerald Wertheim1, 2, Michele Paessler1, 2. 1Children's Hospital of Philadelphia, Philadelphia, PA, USA. 2University of Pennsylvania, Philadelphia, PA, USA

ESSENTIAL THROMBOCYTHEMIA PRESENTING AS SPLENIC INFARCTION Shikha Malhotra, Nidhi Aggarwal. University of Pittsburgh Medical Center (UPMC), Pittsburgh, PA, USA

AUTOIMMUNE MYELOFIBROSIS Rachel A Mariani1, 2, Kristian T Schafernak1, 2, Jeffery Jacobsen3, 4. 1Phoenix Children's Hospital, Phoenix, AZ, USA. 2University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA. 3ARUP Laboratories, Salt Lake City, UT, USA. 4University of Utah, Salt Lake City, UT, USA

MYELOID NEOPLASM WITH JUVENILE MYELOMONOCYTIC LEUKEMIA-LIKE FEATURES AND GERMLINE PATHOGENIC GATA2 VARIANT Clayton Marolt, Yi-Shan Lee. Washington University School of Medicine, St. Louis, MO, USA

TUMOR-RELATED LEUKOCYTOSIS IN AN ADOLESCENT HAVING INI-1 NEGATIVE SARCOMA Kathleen Nicol, Samir Kahwash, Benjamin Kaumeyer, Kristina Brannock. Nationwide Children's Hospital (Columbus, OH), Columbus, OH, USA

CHRONIC MYELOMONOCYTIC LEUKEMIA WITH JUVENILE MYELOMONOCYTIC LEUKEMIA-LIKE MOLECULAR FEATURES IN A 25-YEAR-OLD MAN Chi Young Ok, Sa A. Wang. The University of Texas MD Anderson Cancer Center, Houston, TX, USA

CHRONIC MYELOID LEUKEMIA (CML) IN  AN 11-YEAR-OLD PATIENT Ion Prisneac, Walaa Hammad, Huda Elzahrany, David Howell, Cara Randall, Sharathkumar Bhagavathi, Gustavo Torres. West Virginia University, Morgantown, WV, USA

A CASE OF CHRONIC MYELOID LEUKEMIA (CML) IN ADOLESCENCE AND YOUNG ADULTHOOD (AYA) Jamie Rigney, Michael Greas, Durga Cherukuri, Yan Liu. Loma Linda Health University, Loma Linda, CA, USA

A CASE OF MYELOKATHEXIS ASSOCIATED WITH WHIM SYNDROME Daniel J. Robbins, Weijie Li. Children's Mercy Hospital, Kansas City, MO, USA

11-YEAR-OLD MALE WITH TRIPLE-NEGATIVE ESSENTIAL THROMBOCYTHEMIA Ivo N. Sah Bandar1, Julia T. Geyer1, Nicole E. Kucine2, Sheera Minkowitz2, Madhu Ouseph1. 1Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. 2Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA

LATE ONSET JUVENILE MYELOMONOCYTIC LEUKEMIA WITH INV(2P23Q13) ALK::RANBP2 Birgitta Sander1, 2. 1Karolinska University Hospital, Stockholm Sweden. 2Karolinska Institutet, Stockholm Sweden

JUVENILE MYELOMONOCYTIC LEUKEMIA WITH CONCURRENT T-LYMPHOBLASTIC LEUKEMIA/LYMPHOMA PROGRESSING TO REFRACTORY ACUTE MYELOID LEUKEMIA WITH SOFT TISSUE AND NODAL INVOLVEMENT Melissa Stalling1, Mark Steele1, Carmen Julius1, Matthew Keisling1, Jie Xu1, Matthew Leffew2, Chad Hudson3, Jonathan R. Fromm4, Rachel Mariani5, Daniel A. Arber6, Ashley Eckel3, 4. 1Akron Children's Hospital, Akron, OH, USA. 2Summa Health System, Akron, OH, USA. 3Hematologics, Inc, Seattle, WA, USA. 4University of Washington, Seattle, WA, USA. 5Phoenix Children's Hospital, Phoenix, AZ, USA. 6University of Chicago, Chicago, IL, USA

ESSENTIAL THROMBOCYTHEMIA WITH ACQUIRED VON WILLEBRAND SYNDROME IN A PEDIATRIC PATIENT Ingrid S Tam1, Sarah Tehseen2, Gina Martin2, Kathleen Felton2, Emina E Torlakovic1, 3. 1Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada. 2Department of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada. 3Saskatchewan Health Authority, Saskatoon, SK, Canada

MYELODYSPLASTIC/MYELOPROLIFERATIVE NEOPLASM (MDS/MPN) OCCURRING IN THE SETTING OF GERMLINE PREDISPOSITION (NOONAN SYNDROME) Lisa D. Yuen1, Jacob R. Bledsoe2, Jessica A. Pollard2, Howard J. Weinstein1, Derek Loneman1, Robert P. Hasserjian1. 1Massachusetts General Hospital, Boston, MA, USA. 2Boston Children's Hospital, Boston, MA, USA