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WORKSHOP PROGRAM

Below is the preliminary workshop program. Individual presentations and additional information will be posted shortly.



Wednesday, November 8th

2:00 - 5:30 PM
EXPERIMENTAL HEMATOPATHOLOGY SCIENTIFIC SYMPOSIUM
Chair/Organizer: Christopher Park
Ballroom Center-West

2:00
Welcome Remarks
Christopher Park.

2:03
Inhibition of CDK4 as a potential therapy for natural killer cell lymphoma with MYC overexpression
Kai Fu1, 4, Chengfeng Bi1, Yuhua Huang2, Roshia Ali1, Fang Wang2, Xia Yang2, Alyssa Bouska1, Matthew Lunning1, Wing Chan3, Javeed Iqbal1, Dennis Weisenburger1, Julie Vose1. 1University of Nebraska Medical Center, Omaha, NE, USA.2Sun Yat-sen University Cancer Center, Guangzhou, China.3City of Hope National Medical Center, Duarte, CA, USA.4Roswell Park Cancer Center, Buffalo, NY, USA

2:15
Detecting Actionable Structural Variants with 3D Genomics in archived acute leukemia specimens from unstained bone marrow smears
Adrian Dubuc1, Anthony Schmitt2, Kristin Sikkink2, Logan Van Meter2, Alaina Peterson2, Valentina Nardi3. 1Brigham and Women's Hospital, Boston, MA, USA.2Arima Genomics, Carlsbad, CA, USA.3Mass General Brigham, Boston, MA, USA

2:27
NFB dysregulation in the bone marrow niche drives epigenomic reprogramming of hematopoietic stem cells and myeloid bias
Jennifer Chia1, 2, Apeksha Singh2, 3, Eason Lin2, Alexander Hoffmann2. 1Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA, USA.2Signaling Systems Laboratory, Department of Microbiology, Immunology a Molecular Genetics, University of California, Los Angeles, CA, USA.3UCLA-Caltech Medical Scientist Training Program, Los Angeles, CA, USA

2:39
Hematopoietic stem and progenitor cell vesicles pre-condition the bone marrow vascular niche during transplantation
Stephanie N Hurwitz1, 2, Danielle R Kobulsky1, Seul K Jung1, Peter Kurre1, 3. 1Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA, USA.2Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

2:51
Shared Erythroid and Megakaryocytic Differentiation and Pro-inflammatory Programs in JAK2-mutated Acute Myeloid Leukemia with or without Antecedent Myeloproliferative Neoplasm
Ying Liu, Shenon Sethi, Richard Koche, Qi Gao, Deepika Dilip, Jacob Glass, Xiaotian Sun, Menglei Zhu, Pallavi Galera, Maria Arcila, Ahmet Dogan, Mikhail Roshal, Raajit Rampal, Wenbin Xiao. Memorial Sloan Kettering Cancer Center, New York, NY, USA, New York, NY, USA

3:03
Follicular lymphoma is composed of multiple transcriptional subtypes with unique microenvironment compositions that are independently predictive of overall survival following frontline therapy with rituximab and chemotherapy.
Matthew Klairmont, Christopher Park. New York University School of Medicine, New York, NY, USA

3:15
Integration of Artificial Intelligence with Genomics to assist the diagnosis of hematologic malignancies
Cassandra Love1, Magdalena Czader2, Eric D Hsi3, Kikkeri Naresh4, Elizabeth Thacker5, Sandeep Dave1. 1Duke University, Durham, NC, USA.2Indiana University, Indianapolis, IN, USA.3Wake Forest University, Winston-Salem, NC, USA.4University of Washington, Seattle, WA, USA.5Data driven Bioscience, Durham, NC, USA

3:27
Hi-C as Universal FISH for Genome-Wide Detection of Enhancer-Hijacking Rearrangements in Lymphoma
Russell Ryan1, Jang Cho1, Anna Owczarczyk2, Alec Chu1, Marcin Cieslik1, Anamarija Perry1, Noah Brown1. 1University of Michigan Medical School, Ann Arbor, MI, USA.2Cleveland Clinic, Cleveland, OH, USA

3:39
Analysis of Clonal Variant Allelic Frequency in Bulk vs Sorted population of Cells Using Aberrant Surface Epitopes Identified in Myelodysplastic Syndrome (MDS) via Single-Cell Sequencing
Rohan Kodgule1, Karolyn Oetjen2, Jennifer Ponce3, Jennifer A. Foltz2, Joshua Robinson1, Cara Shirai1, Tianjiao Wang1, Todd Fehniger2, Meagan Jacoby2, Matthew Walter2, Eric J. Duncavage1. 1Washington University in St. Louis, Pathology And Immunology, St. Louis, MO, USA.2Washington University in St. Louis, Division Of Oncology, Department Of Internal Medicine, St. Louis, MO, USA.3Washington University in St. Louis, MGI, St. Louis, MO, USA

3:51
Break
.

4:10
RAF-Independent MAP2K1 Mutations Drive Histiocytic Neoplasms In Vivo and Provide Insights into Cellular Origin and Future Therapeutic Strategies
Benjamin H. Durham1, 2, Michael Singer1, Salima Benbarche1, Caroline Erickson1, Jahan Rahman1, David B. Solit3, Matthew Witkowski4, Neal Rosen1, Omar Abdel-Wahab1, 5, Eli L. Diamond6. 1Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.2Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.3Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.4Pediatrics-Hematology/Oncology and Bone Marrow Transplantation, Aurora, CO, USA.5Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.6Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

4:22
Gasdermin D Mediates Inflammation-Driven Pathogenesis of Myelodysplastic Syndromes
Kehan Ren, Ermin Li, Yijie Liu, Xu Han, Honghao Bi, Peng Ji. Northwestern University, Chicago, IL, USA

4:34
The role of CABIN-1 in the pathogenesis of idiopathic Multicentric Castleman Disease
Dorottya Laczko1, David Fajgenbaum2, Taku Kambayashi1. 1Perelman School of Medicine at the University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia, PA, USA.2Perelman School of Medicine at the University of Pennsylvania, Division of Translational Medicine a Human Genetics, Philadelphia, PA, USA

4:46
Polytypic B-cells (PBCs), B-cell lymphoproliferative disorders (B-LPDs), and neoplastic T-cells divergently differentiate from TET2-/DNMT3A-mutated clonal hematopoiesis (CH) in patients with follicular helper T-cell (TFH) lymphoproliferative disorders (TFH-LPDs)
Natasha Lewis1, Kseniya Petrova-Drus1, 2, Rohan Sardana1, Qi Gao1, Shenon Sethi1, Wenbin Xiao1, Mikhail Roshal1, Jeeyeon Baik1, Himanshu Bhurtel1, Alison Moskowitz3, Steven Horwitz3, Ahmet Dogan1. 1Hematopathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.2Diagnostic Molecular Pathology Service, Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.3Lymphoma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA

4:58
Dysregulated FOXM1/PLK1 signaling axis in diffuse large B cell lymphoma
Hua He1, Fang Yu1, Loretta Nastoupil2, Zijun Xu-Monette1, 3, Ky Pham1, C. Cameron Yin1, Yaling Yang1, Shimin Hu1, Ken Young1, 3, Lan Pham1, 4, M. James You1, 5. 1Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.2Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.3Division of Hematopathology, Duke University Medical Center, Durham, NC, USA.4Oncology Discovery, AbbVie Inc., South San Francisco, CA, USA.5The University of Texas MD Anderson Cancer Center and UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

5:10
Kikuchi-Fujimoto Disease is a Localized IFN response to Double Stranded RNA Released by Apoptosis and Mediated by Inflammatory Macrophages, PDC and Cytotoxic T cells.
Vinodh Pillai1, Anna Eichinger2, David Smith1, Eduardo Esteva2, Xiaxu Yang1, Mei Zhang1, Kai Tan1, Christopher Park2, Boris Reizis2. 1The Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, PA, USA.2New York University School of Medicine, New York, NY, USA
6:10 - 7:10 PM
LECTURE
Ballroom Center-West

6:10
Emerging molecular subgroups in PTCL-NOS
Javeed Iqbal, PhD . Univ. of Nebraska, Omaha
7:10 - 8:40 PM
RECEPTION
Foyer