Thank you for joining us at the SH-EAHP 2021 Workshop.
The goal of this workshop was to examine cases of transformation and transdifferentiation (lineage switch) in lymphoid malignancies in respect to their morphology and genetic findings as well as address diagnostic challenges including changes in morphology caused by novel treatments with a variety of targeted therapies including inhibitor drugs. Cases of lymphoma trans-differentiation and cases which do not meet WHO criteria for transformation and yet show significant phenotypic and/or genetic changes were particularly welcomed.
The areas of particular interest were to address specific genetic abnormalities contributing to the transformation or transdifferentiation including rearrangements of MYC and BCL6 genes and mutations of TP53 gene and highlight novel insights into molecular mechanisms contributing to tumor progression and lineage switch in lymphoid malignancies. Another focus of this workshop was elucidating the impact of targeted therapies as potential contributors to transformation and transdifferentiation and redefining the role of the hematopathologists in the light of the new genetic and therapeutic advances.
Extensive molecular characterization (the whole exome sequencing combined with whole genome RNA expression analysis with interpretation of these data) was offered free of charge to the workshop participants for inclusion in their presentations.
Lectures on the status on the diagnosis and management of patients who experienced disease progression were presented at this Workshop
Ahmet Dogan, MD, PhD
Mariusz A. Wasik, MD
Amy Duffield, MD
James R. Cook, MD, PhD
Magdalena Czader, MD, PhD
Reza Nejati, MD
Wenbin Xiao, MD, PhD
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A unique feature of this workshop will be addition of in-depth molecular analysis of selected cases to reveal potential pathogenic genomic aberrations and/or identify novel therapeutic targets.